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AZIN1 antizyme inhibitor 1 [ Sorex araneus (European shrew) ]

Gene ID: 101548658, updated on 19-May-2024

Summary

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Gene symbol
AZIN1
Gene description
antizyme inhibitor 1
See related
EnsemblRapid:ENSSARG00000001295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Sorex araneus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Soricinae; Sorex
Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Orthologs
human mouse all
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Genomic context

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See AZIN1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_04 current mSorAra2.pri (GCF_027595985.1) 2 NC_073303.1 (123606289..123635993)
101 previous assembly SorAra2.0 (GCF_000181275.1) Unplaced Scaffold NW_004545883.1 (21423914..21453390)

Chromosome 2 - NC_073303.1Genomic Context describing neighboring genes Neighboring gene BAALC binder of MAP3K1 and KLF4 Neighboring gene ATPase H+ transporting V1 subunit C1 Neighboring gene uncharacterized LOC129402596 Neighboring gene KLF transcription factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Kahana C. Essays Biochem, 2009 Nov 4. PMID 20095969

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ornithine decarboxylase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ornithine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in putrescine biosynthetic process from ornithine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
antizyme inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291520.1 → NP_001278449.1  antizyme inhibitor 1

    See identical proteins and their annotated locations for NP_001278449.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAQBIA010000019
    Related
    ENSSARP00000001180.2, ENSSART00000001290.2
    Conserved Domains (2) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
    COG0019
    Location:40 → 405
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

  2. NM_001301748.1 → NP_001288677.1  antizyme inhibitor 1

    See identical proteins and their annotated locations for NP_001288677.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAQBIA010000019
    Conserved Domains (2) summary
    cd06831
    Location:26 → 419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
    COG0019
    Location:40 → 405
    LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_027595985.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSorAra2.pri

Genomic

  1. NC_073303.1 Reference mSorAra2.pri

    Range
    123606289..123635993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_055124222.1 → XP_054980197.1  antizyme inhibitor 1 isoform X1

Nucleotide Protein
Heading Accession and Version

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