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ROR1-AS1 ROR1 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 101927034, updated on 10-Oct-2023

Summary

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Official Symbol
ROR1-AS1provided by HGNC
Official Full Name
ROR1 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:40508
See related
Ensembl:ENSG00000223949 AllianceGenome:HGNC:40508
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 1.4) See more
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Genomic context

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Location:
1p31.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (64094442..64113791, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63970220..63989553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64560125..64579474, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene receptor tyrosine kinase like orphan receptor 1 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:64620864-64621414 Neighboring gene uncharacterized LOC105378773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64661738-64662238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64662239-64662739 Neighboring gene Sharpr-MPRA regulatory region 11272 Neighboring gene ubiquitin conjugating enzyme E2 U Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:64728314-64729513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504. Wu X, et al. Aging (Albany NY), 2020 Dec 19. PMID 33401251, Free PMC Article
  2. Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p. Zhang L, et al. J Recept Signal Transduct Res, 2021 Dec. PMID 33081599
  3. LncRNA ROR1‑AS1 high expression and its prognostic significance in liver cancer. Zhang Z, et al. Oncol Rep, 2020 Jan. PMID 31746401, Free PMC Article
  4. Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375. Xu N, et al. J BUON, 2019 Nov-Dec. PMID 31983094
  5. Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504. Chen Q, et al. PLoS One, 2020. PMID 31929567, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
    Title: ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells.
  2. Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
    Title: Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p.
  3. ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
    Title: ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway.
  4. LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
    Title: LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.
  5. Results suggested that ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC.
    Title: Long noncoding RNA ROR1-AS1 enhances lung adenocarcinoma metastasis and induces epithelial-mesenchymal transition by sponging miR-375.
  6. Data found that expression of lncRNA ROR1AS1 was significantly increased in hepatocellular carcinoma (HCC) patients and associated with several clinical features and an undesirable prognosis; therefore, lncRNA ROR1AS1 may serve as a useful biomarker for the prognosis of patients with HCC.
    Title: LncRNA ROR1‑AS1 high expression and its prognostic significance in liver cancer.
  7. ROR1-AS1 directly bound with miR-504 and act as a molecular sponge to decrease miR-504 expression. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis.
    Title: Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110665.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK096291, AL445205

  2. NR_110666.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' and 3' structure and is shorter compared to variant 1.
    Source sequence(s)
    AL445205, BC040909
    Related
    ENST00000412349.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    64094442..64113791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    63970220..63989553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases