EMSLR E2F1 mRNA stabilizing lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: EMSLRprovided by HGNC
Official Full Name: E2F1 mRNA stabilizing lncRNAprovided by HGNC
Primary source: HGNC:HGNC:54408
See related: MIM:618575; AllianceGenome:HGNC:54408
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EMS; BCCE4
Expression: Broad expression in kidney (RPKM 1.1), stomach (RPKM 0.8) and 19 other tissues See more
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Genomic context

Location:: 7q22.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (101308307..101311339)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (102631782..102634814)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100951588..100954620)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1.
Title: E2F1-induced lncRNA, EMSLR regulates lncRNA LncPRESS1.
Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis.
Title: Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis.
Study reports the lncRNA E2F1 mRNA stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability.
Title: Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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Other Names

Bladder cancer Cell Cytoplasm-Enriched abundant transcript 4
E2F1 mRNA stabilizing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.