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Dohh deoxyhypusine hydroxylase/monooxygenase [ Mus musculus (house mouse) ]

Gene ID: 102115, updated on 2-Nov-2024

Summary

Official Symbol
Dohhprovided by MGI
Official Full Name
deoxyhypusine hydroxylase/monooxygenaseprovided by MGI
Primary source
MGI:MGI:1915964
See related
Ensembl:ENSMUSG00000078440 AllianceGenome:MGI:1915964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hlrc1; 1110033C18Rik
Summary
Enables deoxyhypusine monooxygenase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Predicted to be active in cytosol. Is expressed in nervous system; retina; and skeletal muscle. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 72.2), adrenal adult (RPKM 53.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dohh in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81220268..81224186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81384434..81388352)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 12 Neighboring gene tektin bundle interacting protein 1 Neighboring gene fizzy and cell division cycle 20 related 1 Neighboring gene STARR-seq mESC enhancer starr_27331 Neighboring gene STARR-seq mESC enhancer starr_27332 Neighboring gene predicted gene, 48551 Neighboring gene microRNA 6913 Neighboring gene predicted gene, 48552 Neighboring gene small integral membrane protein 24

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deoxyhypusine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deoxyhypusine monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables deoxyhypusine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables deoxyhypusine monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
deoxyhypusine hydroxylase
Names
HEAT-like (PBS lyase) repeat containing 1
deoxyhypusine dioxygenase
deoxyhypusine monooxygenase
NP_598725.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133964.3NP_598725.2  deoxyhypusine hydroxylase

    See identical proteins and their annotated locations for NP_598725.2

    Status: VALIDATED

    Source sequence(s)
    AC155937
    Consensus CDS
    CCDS35997.1
    UniProtKB/Swiss-Prot
    Q8BNT3, Q8BTD5, Q99LN9
    Related
    ENSMUSP00000072534.7, ENSMUST00000072751.13
    Conserved Domains (2) summary
    COG1413
    Location:37292
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:3967
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81220268..81224186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)