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Ankrd10 ankyrin repeat domain 10 [ Mus musculus (house mouse) ]

Gene ID: 102334, updated on 28-Oct-2024

Summary

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Official Symbol
Ankrd10provided by MGI
Official Full Name
ankyrin repeat domain 10provided by MGI
Primary source
MGI:MGI:1921840
See related
Ensembl:ENSMUSG00000031508 AllianceGenome:MGI:1921840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833425P12Rik
Summary
Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; branchial arch; genitourinary system; limb; and maxillary process. Orthologous to human ANKRD10 (ankyrin repeat domain 10). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 34.9), thymus adult (RPKM 31.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd10 in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11661581..11694617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11611581..11635926, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1 Neighboring gene STARR-seq mESC enhancer starr_20718 Neighboring gene STARR-positive B cell enhancer ABC_E9307 Neighboring gene STARR-seq mESC enhancer starr_20722 Neighboring gene microRNA 7238 Neighboring gene STARR-seq mESC enhancer starr_20723 Neighboring gene sperm acrosome associated 7B Neighboring gene ribosomal protein S3A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167967.2 → NP_001161439.1  ankyrin repeat domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001161439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a distinct 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK031808, AK039879, AK050983
    Consensus CDS
    CCDS52479.1
    UniProtKB/TrEMBL
    Q8BG46
    Related
    ENSMUSP00000131657.2, ENSMUST00000169782.3
    Conserved Domains (3) summary
    cd00204
    Location:56 → 177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:62 → 154
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:56 → 88
    ANK; ANK repeat [structural motif]

  2. NM_001281974.1 → NP_001268903.1  ankyrin repeat domain-containing protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001268903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK050983, AK082875, AK084456, AV319211
    UniProtKB/Swiss-Prot
    Q99LW0
    UniProtKB/TrEMBL
    Q8BG46

  3. NM_001281975.1 → NP_001268904.1  ankyrin repeat domain-containing protein 10 isoform 4

    See identical proteins and their annotated locations for NP_001268904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK050983, AK081754, AK084456, AV319211
    UniProtKB/TrEMBL
    Q8BG46

  4. NM_133971.3 → NP_598732.2  ankyrin repeat domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_598732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform 1.
    Source sequence(s)
    AK050983, AK082875, AK084456, AV319211
    Consensus CDS
    CCDS22098.1
    UniProtKB/Swiss-Prot
    Q8BGB6, Q99LW0
    Related
    ENSMUSP00000033905.6, ENSMUST00000033905.13
    Conserved Domains (3) summary
    cd00204
    Location:56 → 177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:62 → 154
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:56 → 88
    ANK; ANK repeat [structural motif]

RNA

  1. NR_030781.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 1, including the use of an alternate promoter. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK014768, AK039879

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11661581..11694617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508685.5 → XP_006508748.1  ankyrin repeat domain-containing protein 10 isoform X1

    Conserved Domains (2) summary
    COG0666
    Location:46 → 188
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:56 → 88
    ANK; ANK repeat [structural motif]

  2. XM_006508686.5 → XP_006508749.1  ankyrin repeat domain-containing protein 10 isoform X2

    Conserved Domains (2) summary
    sd00045
    Location:19 → 48
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:23 → 105
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006508691.5 → XP_006508754.1  ankyrin repeat domain-containing protein 10 isoform X7

    See identical proteins and their annotated locations for XP_006508754.1

  4. XM_006508688.5 → XP_006508751.1  ankyrin repeat domain-containing protein 10 isoform X5

  5. XM_030243218.2 → XP_030099078.1  ankyrin repeat domain-containing protein 10 isoform X3

    Conserved Domains (2) summary
    sd00045
    Location:19 → 48
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:23 → 105
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030243222.2 → XP_030099082.1  ankyrin repeat domain-containing protein 10 isoform X8

  7. XM_030243221.2 → XP_030099081.1  ankyrin repeat domain-containing protein 10 isoform X6

  8. XM_036153709.1 → XP_036009602.1  ankyrin repeat domain-containing protein 10 isoform X8

  9. XM_006508687.5 → XP_006508750.1  ankyrin repeat domain-containing protein 10 isoform X4

    Conserved Domains (2) summary
    COG0666
    Location:46 → 188
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:56 → 88
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LW0.2 GenPept UniProtKB/Swiss-Prot:Q99LW0

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