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Cd276 CD276 antigen [ Mus musculus (house mouse) ]

Gene ID: 102657, updated on 2-Nov-2024

Summary

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Official Symbol
Cd276provided by MGI
Official Full Name
CD276 antigenprovided by MGI
Primary source
MGI:MGI:2183926
See related
Ensembl:ENSMUSG00000035914 AllianceGenome:MGI:2183926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7h3; B7-H3; B7RP-2; 6030411F23Rik
Summary
Enables identical protein binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including embryo endoderm; genitourinary system; hemolymphoid system; liver; and musculoskeletal system. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 25.4), CNS E14 (RPKM 11.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Cd276 in Genome Data Viewer
Location:
9 B; 9 31.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58431581..58463437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58524300..58555033, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930461G14 gene Neighboring gene predicted gene, 32768 Neighboring gene inhibitory synaptic factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6742 Neighboring gene predicted gene, 53528 Neighboring gene STARR-positive B cell enhancer ABC_E1387 Neighboring gene neuroplastin Neighboring gene REC114 meiotic recombination protein Neighboring gene predicted gene 20620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Luo L, et al. J Immunol, 2004 Nov 1. PMID 15494491
  2. B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma. Nagashima O, et al. J Immunol, 2008 Sep 15. PMID 18768862
  3. CD40-activated apoptotic tumor cell-pulsed dendritic cell could potentially elicit antitumor immune response: involvement of up-regulation of B7-H3 expression. Chen C, et al. J Immunother, 2009 Jan. PMID 19307991
  4. B7-H3 regulates the development of experimental allergic conjunctivitis in mice. Fukushima A, et al. Immunol Lett, 2007 Oct 31. PMID 17825429
  5. 4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells. Zhou YH, et al. Tissue Antigens, 2007 Aug. PMID 17610414

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
    Title: CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer.
  2. CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-beta/SMAD signaling.
    Title: CD276 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma through the TGF-β/SMAD signaling.
  3. Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells.
    Title: Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells.
  4. B7-H3 promotes angiogenesis in rheumatoid arthritis.
    Title: B7-H3 promotes angiogenesis in rheumatoid arthritis.
  5. Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer.
    Title: Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer.
  6. EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression.
    Title: EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression.
  7. Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cellsdagger.
    Title: Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells†.
  8. Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
    Title: Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
  9. B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
    Title: B7-H3 blockade decreases macrophage inflammatory response and alleviates clinical symptoms of arthritis.
  10. B7H3 expression and significance in idiopathic pulmonary fibrosis.
    Title: B7H3 expression and significance in idiopathic pulmonary fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (11)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CD276 antigen
Names
B7 homolog 3
costimulatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424677.1 → NP_001411606.1  CD276 antigen isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT030640

  2. NM_001424678.1 → NP_001411607.1  CD276 antigen isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CT030640

  3. NM_001424679.1 → NP_001411608.1  CD276 antigen isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT030640
    UniProtKB/Swiss-Prot
    Q8VE98
    UniProtKB/TrEMBL
    A6MDC5

  4. NM_001424680.1 → NP_001411609.1  CD276 antigen isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    CT030640

  5. NM_001424681.1 → NP_001411610.1  CD276 antigen isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    CT030640

  6. NM_133983.5 → NP_598744.1  CD276 antigen isoform 2 precursor

    See identical proteins and their annotated locations for NP_598744.1

    Status: VALIDATED

    Source sequence(s)
    CT030640
    Consensus CDS
    CCDS23244.1
    UniProtKB/Swiss-Prot
    Q8VE98
    UniProtKB/TrEMBL
    A6MDC5
    Related
    ENSMUSP00000129418.2, ENSMUST00000165365.3
    Conserved Domains (3) summary
    cd00098
    Location:149 → 235
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:37 → 138
    IG_like; Immunoglobulin like
    cl11960
    Location:44 → 139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58431581..58463437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE98.1 GenPept UniProtKB/Swiss-Prot:Q8VE98

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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