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SYT15B synaptotagmin 15B [ Homo sapiens (human) ]

Gene ID: 102724488, updated on 2-Nov-2024

Summary

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Official Symbol
SYT15Bprovided by HGNC
Official Full Name
synaptotagmin 15Bprovided by HGNC
Primary source
HGNC:HGNC:51487
See related
Ensembl:ENSG00000277758 AllianceGenome:HGNC:51487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung (RPKM 7.5), lymph node (RPKM 1.7) and 17 other tissues See more
Orthologs
all
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Genomic context

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See SYT15B in Genome Data Viewer
Location:
10q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47744717..47763592, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48636126..48655007, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene annexin A8 Neighboring gene uncharacterized LOC102724603 Neighboring gene shieldin complex subunit 2 pseudogene 3 Neighboring gene uncharacterized LOC124902422 Neighboring gene uncharacterized LOC102724593 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47089387-47089886 Neighboring gene neuropeptide Y receptor Y4-2 Neighboring gene uncharacterized LOC124902423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
synaptotagmin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370182.1 → NP_001357111.1  synaptotagmin-15 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    FO681492
    Consensus CDS
    CCDS91240.1
    UniProtKB/Swiss-Prot
    X6R8R1
    Related
    ENSP00000485217.1, ENST00000623662.4
    Conserved Domains (2) summary
    cd08390
    Location:202 → 322
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:332 → 469
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

  2. NM_001370183.1 → NP_001357112.1  synaptotagmin-15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    FO681492
    UniProtKB/TrEMBL
    A8K2C1
    Conserved Domains (2) summary
    cd08390
    Location:156 → 276
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:286 → 423
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

  3. NM_001370184.1 → NP_001357113.1  synaptotagmin-15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    FO681492
    Consensus CDS
    CCDS91239.1
    UniProtKB/Swiss-Prot
    A5D6W8, Q5VY53, Q5VY55, Q7Z439, Q7Z440, Q9BQS2
    UniProtKB/TrEMBL
    A8K2C1
    Related
    ENSP00000478933.3, ENST00000615923.4
    Conserved Domains (2) summary
    cd08390
    Location:149 → 269
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:279 → 416
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

  4. NM_001370185.1 → NP_001357114.1  synaptotagmin-15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    FO681492
    UniProtKB/TrEMBL
    A8K2C1
    Conserved Domains (2) summary
    cd08390
    Location:103 → 223
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:233 → 370
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

  5. NM_001370186.1 → NP_001357115.1  synaptotagmin-15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    DB474425, FO681492
    UniProtKB/TrEMBL
    B4DEH7
    Conserved Domains (2) summary
    cd08390
    Location:33 → 153
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08409
    Location:163 → 300
    C2B_Synaptotagmin-15; C2 domain second repeat present in Synaptotagmin 15

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    47744717..47763592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540438.4 → XP_011538740.1  synaptotagmin-15 isoform X1

    See identical proteins and their annotated locations for XP_011538740.1

    Conserved Domains (2) summary
    cd08390
    Location:209 → 329
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:339 → 438
    C2; C2 domain

  2. XM_011540436.4 → XP_011538738.1  synaptotagmin-15 isoform X1

    See identical proteins and their annotated locations for XP_011538738.1

    Conserved Domains (2) summary
    cd08390
    Location:209 → 329
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:339 → 438
    C2; C2 domain

  3. XM_011540437.3 → XP_011538739.1  synaptotagmin-15 isoform X1

    See identical proteins and their annotated locations for XP_011538739.1

    Conserved Domains (2) summary
    cd08390
    Location:209 → 329
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:339 → 438
    C2; C2 domain

  4. XM_047424437.1 → XP_047280393.1  synaptotagmin-15 isoform X2

  5. XM_011540435.4 → XP_011538737.1  synaptotagmin-15 isoform X1

    See identical proteins and their annotated locations for XP_011538737.1

    Conserved Domains (2) summary
    cd08390
    Location:209 → 329
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:339 → 438
    C2; C2 domain

  6. XM_047424435.1 → XP_047280391.1  synaptotagmin-15 isoform X1

RNA

  1. XR_001747444.3 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160001.1 Reference GRCh38.p14 PATCHES

    Range
    5568..24443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332441.1 → XP_054188416.1  synaptotagmin-15 isoform X1

  2. XM_054332439.1 → XP_054188414.1  synaptotagmin-15 isoform X1

  3. XM_054332443.1 → XP_054188418.1  synaptotagmin-15 isoform X1

  4. XM_054332444.1 → XP_054188419.1  synaptotagmin-15 isoform X2

  5. XM_054332442.1 → XP_054188417.1  synaptotagmin-15 isoform X1

  6. XM_054332440.1 → XP_054188415.1  synaptotagmin-15 isoform X1

RNA

  1. XR_008485776.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    48636126..48655007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364475.1 → XP_054220450.1  synaptotagmin-15 isoform X1

  2. XM_054364480.1 → XP_054220455.1  synaptotagmin-15 isoform X2

  3. XM_054364474.1 → XP_054220449.1  synaptotagmin-15 isoform X1

  4. XM_054364478.1 → XP_054220453.1  synaptotagmin-15 isoform X1

  5. XM_054364479.1 → XP_054220454.1  synaptotagmin-15 isoform X2

  6. XM_054364477.1 → XP_054220452.1  synaptotagmin-15 isoform X1

  7. XM_054364476.1 → XP_054220451.1  synaptotagmin-15 isoform X1

RNA

  1. XR_008488153.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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