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POTEB3 POTE ankyrin domain family member B3 [ Homo sapiens (human) ]

Gene ID: 102724631, updated on 3-Apr-2024

Summary

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Official Symbol
POTEB3provided by HGNC
Official Full Name
POTE ankyrin domain family member B3provided by HGNC
Primary source
HGNC:HGNC:51240
See related
Ensembl:ENSG00000278522 AllianceGenome:HGNC:51240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POTEB; POTE-15
Expression
Restricted expression toward testis (RPKM 3.9) See more
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Genomic context

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See POTEB3 in Genome Data Viewer
Location:
15q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (21405401..21440499, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (18748387..18783424, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CXADR pseudogene 2 Neighboring gene GRAM domain containing 4 pseudogene 6 Neighboring gene microRNA 3118-3 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC105369227 Neighboring gene neurofibromin 1 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Personalized copy number and segmental duplication maps using next-generation sequencing. Alkan C, et al. Nat Genet, 2009 Oct. PMID 19718026, Free PMC Article
  2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Bera TK, et al. Gene, 2004 Aug 4. PMID 15276201
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Bera TK, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12475935, Free PMC Article
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
  5. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of POTE ankyrin domain family, member B (POTEB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC87614, MGC119371, MGC119372, MGC119373, MGC156116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
POTE ankyrin domain family member B3
Names
ANKRD26-like family B member 1
POTE ankyrin domain family member B
POTE ankyrin domain family, member B-like
prostate, ovary, testis-expressed protein on chromosome 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207355.5 → NP_997238.2  POTE ankyrin domain family member B3

    See identical proteins and their annotated locations for NP_997238.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC060814
    Consensus CDS
    CCDS73690.1
    UniProtKB/Swiss-Prot
    A0A096LPD0, A0JP26, Q6NXN7, Q6S5H4, Q6S5H7
    UniProtKB/TrEMBL
    A0A087X187
    Related
    ENSP00000483103.1, ENST00000611217.5
    Conserved Domains (4) summary
    cd00204
    Location:167 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:177 → 269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:143 → 193
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]

RNA

  1. NR_110752.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons but includes alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC060814, BC066981, BC127123
    Related
    ENST00000612601.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    21405401..21440499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543797.3 → XP_011542099.1  POTE ankyrin domain family member B3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JQ08
    Conserved Domains (2) summary
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]
    cl39094
    Location:158 → 361
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_047432107.1 → XP_047288063.1  POTE ankyrin domain family member B3 isoform X1

    UniProtKB/TrEMBL
    A0A0C4DH93
    Related
    ENSP00000485523.1, ENST00000624267.3

  3. XM_011543796.3 → XP_011542098.1  POTE ankyrin domain family member B3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JQ08
    Conserved Domains (2) summary
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]
    cl39094
    Location:158 → 361
    Ank_2; Ankyrin repeats (3 copies)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    1961872..2029684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332571.1 → XP_054188546.1  POTE ankyrin domain family member B3 isoform X4

    UniProtKB/TrEMBL
    Q495V6

  2. XM_054332574.1 → XP_054188549.1  POTE ankyrin domain family member B3 isoform X3

  3. XM_054332572.1 → XP_054188547.1  POTE ankyrin domain family member B3 isoform X1

    UniProtKB/TrEMBL
    A0A0C4DH93

  4. XM_054332573.1 → XP_054188548.1  POTE ankyrin domain family member B3 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187602.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    163348..198439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329031.1 → XP_054185006.1  POTE ankyrin domain family member B3 isoform X3

  2. XM_054329029.1 → XP_054185004.1  POTE ankyrin domain family member B3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JQB7

  3. XM_054329030.1 → XP_054185005.1  POTE ankyrin domain family member B3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    18748387..18783424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377203.1 → XP_054233178.1  POTE ankyrin domain family member B3 isoform X3

  2. XM_054377201.1 → XP_054233176.1  POTE ankyrin domain family member B3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JQB7

  3. XM_054377202.1 → XP_054233177.1  POTE ankyrin domain family member B3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JP26.2 GenPept UniProtKB/Swiss-Prot:A0JP26

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