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SPEG striated muscle enriched protein kinase [ Homo sapiens (human) ]

Gene ID: 10290, updated on 2-Nov-2024

Summary

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Official Symbol
SPEGprovided by HGNC
Official Full Name
striated muscle enriched protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:16901
See related
Ensembl:ENSG00000072195 MIM:615950; AllianceGenome:HGNC:16901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPEG; CNM5; APEG1; MYLK6; APEG-1; SPEGbeta; SPEGalpha
Summary
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016]
Expression
Broad expression in endometrium (RPKM 4.8), prostate (RPKM 4.5) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See SPEG in Genome Data Viewer
Location:
2q35
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219434843..219493629)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219919623..219978369)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220299565..220358351)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aspartyl aminopeptidase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12356 Neighboring gene DNPEP antisense RNA 1 Neighboring gene desmin locus control region Neighboring gene VISTA enhancer hs2169 Neighboring gene desmin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220313846-220314453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220315912-220316716 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:220317062-220318261 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:220325404-220325584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220329861-220330528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220330529-220331194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220331442-220331984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220339972-220340679 Neighboring gene Sharpr-MPRA regulatory region 8597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220341387-220342094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220348981-220349782 Neighboring gene ASIC4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 15624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220361035-220361852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220361853-220362670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220362671-220363488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17153 Neighboring gene SPEG neighbor Neighboring gene GDP-mannose pyrophosphorylase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif. Hsieh CM, et al. J Biol Chem, 1999 May 14. PMID 10318857
  2. A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation. Gurgel-Giannetti J, et al. Neuromuscul Disord, 2021 Nov. PMID 34742623
  3. Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells. Chen YH, et al. J Biol Chem, 2001 Dec 14. PMID 11606591
  4. Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy. Almannai M, et al. Circ Genom Precis Med, 2021 Apr. PMID 33794647, Free PMC Article
  5. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. Levitas A, et al. PLoS Genet, 2020 Sep. PMID 32925938, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation.
    Title: A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation.
  2. Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy.
    Title: Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy.
  3. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
    Title: Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
  4. Novel SPEG variant cause centronuclear myopathy in China.
    Title: Novel SPEG variant cause centronuclear myopathy in China.
  5. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.
    Title: A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.
  6. Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.
    Title: Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.
  7. Clinicians should consider evaluating a centronuclear myopathies patient for SPEG mutations even in the absence of centronuclear myopathies features
    Title: Novel SPEG mutations in congenital myopathies: Genotype-phenotype correlations.
  8. SPEG is present in cardiac muscle, where it plays a critical role; therefore, individuals with SPEG mutations additionally present with dilated cardiomyopathy.
    Title: SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
  9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Myopathy, centronuclear, 5
MedGen: C4014814 OMIM: 615959 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1297, MGC12676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
striated muscle preferentially expressed protein kinase
Names
SPEG complex locus
aortic preferentially expressed gene 1
aortic preferentially expressed protein 1
nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury
NP_001166947.1
NP_005867.3
XP_005246294.1
XP_005246296.1
XP_005246297.1
XP_005246298.1
XP_005246299.1
XP_006712252.1
XP_006712256.1
XP_011508781.1
XP_016858648.2
XP_016858650.2
XP_016858651.2
XP_024308294.2
XP_047298847.1
XP_047298848.1
XP_047298849.1
XP_047298850.1
XP_047298851.1
XP_047298852.1
XP_047298853.1
XP_047298854.1
XP_047298856.1
XP_047298857.1
XP_047298858.1
XP_047298859.1
XP_047298860.1
XP_047298861.1
XP_047298862.1
XP_047298863.1
XP_047298864.1
XP_047298865.1
XP_047298866.1
XP_047298867.1
XP_047298868.1
XP_047298870.1
XP_047298873.1
XP_047298874.1
XP_047298875.1
XP_047298876.1
XP_047298877.1
XP_047298878.1
XP_047298879.1
XP_054196108.1
XP_054196109.1
XP_054196110.1
XP_054196111.1
XP_054196112.1
XP_054196113.1
XP_054196114.1
XP_054196115.1
XP_054196116.1
XP_054196117.1
XP_054196118.1
XP_054196119.1
XP_054196120.1
XP_054196121.1
XP_054196122.1
XP_054196123.1
XP_054196124.1
XP_054196125.1
XP_054196126.1
XP_054196127.1
XP_054196128.1
XP_054196129.1
XP_054196130.1
XP_054196131.1
XP_054196132.1
XP_054196133.1
XP_054196134.1
XP_054196135.1
XP_054196136.1
XP_054196137.1
XP_054196138.1
XP_054196139.1
XP_054196140.1
XP_054196141.1
XP_054196142.1
XP_054196143.1
XP_054196144.1
XP_054196145.1
XP_054196146.1
XP_054196147.1
XP_054196148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051022.1 RefSeqGene

    Range
    5629..64415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173476.2 → NP_001166947.1  striated muscle preferentially expressed protein kinase isoform 4

    See identical proteins and their annotated locations for NP_001166947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1. This variant corresponds to the mouse APEG-1 variant described in PubMed ID: 10973969.
    Source sequence(s)
    AC053503, BM677138, DA063220
    Consensus CDS
    CCDS54432.1
    UniProtKB/Swiss-Prot
    Q15772
    Related
    ENSP00000379919.1, ENST00000396688.5
    Conserved Domains (2) summary
    cd00096
    Location:20 → 22
    Ig; Ig strand A [structural motif]
    cl11960
    Location:20 → 110
    Ig; Immunoglobulin domain

  2. NM_005876.5 → NP_005867.3  striated muscle preferentially expressed protein kinase isoform 1

    See identical proteins and their annotated locations for NP_005867.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). This variant corresponds to the mouse SPEGbeta variant described in PubMed ID: 10973969.
    Source sequence(s)
    AC053503
    Consensus CDS
    CCDS42824.1
    UniProtKB/Swiss-Prot
    A8K0G6, A8MRU0, Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9
    Related
    ENSP00000311684.7, ENST00000312358.12
    Conserved Domains (8) summary
    cd00096
    Location:1502 → 1571
    Ig; Immunoglobulin domain
    smart00408
    Location:882 → 949
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2966 → 3218
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:722 → 811
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:1598 → 1854
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2962 → 3218
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:812 → 868
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:745 → 812
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219434843..219493629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442891.1 → XP_047298847.1  striated muscle preferentially expressed protein kinase isoform X2

  2. XM_011510479.3 → XP_011508781.1  striated muscle preferentially expressed protein kinase isoform X1

    Conserved Domains (8) summary
    cd00096
    Location:1512 → 1581
    Ig; Immunoglobulin domain
    smart00408
    Location:892 → 959
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2976 → 3228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:732 → 821
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:1608 → 1864
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2972 → 3228
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:822 → 878
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:755 → 822
    Ig; Immunoglobulin domain

  3. XM_047442893.1 → XP_047298849.1  striated muscle preferentially expressed protein kinase isoform X4

  4. XM_047442892.1 → XP_047298848.1  striated muscle preferentially expressed protein kinase isoform X3

  5. XM_047442894.1 → XP_047298850.1  striated muscle preferentially expressed protein kinase isoform X5

  6. XM_047442895.1 → XP_047298851.1  striated muscle preferentially expressed protein kinase isoform X8

  7. XM_017003159.3 → XP_016858648.2  striated muscle preferentially expressed protein kinase isoform X12

  8. XM_047442901.1 → XP_047298857.1  striated muscle preferentially expressed protein kinase isoform X15

  9. XM_017003161.3 → XP_016858650.2  striated muscle preferentially expressed protein kinase isoform X16

  10. XM_017003162.3 → XP_016858651.2  striated muscle preferentially expressed protein kinase isoform X17

  11. XM_024452526.2 → XP_024308294.2  striated muscle preferentially expressed protein kinase isoform X19

  12. XM_047442902.1 → XP_047298858.1  striated muscle preferentially expressed protein kinase isoform X18

  13. XM_047442906.1 → XP_047298862.1  striated muscle preferentially expressed protein kinase isoform X23

  14. XM_047442903.1 → XP_047298859.1  striated muscle preferentially expressed protein kinase isoform X20

  15. XM_005246239.3 → XP_005246296.1  striated muscle preferentially expressed protein kinase isoform X11

    Conserved Domains (8) summary
    cd00096
    Location:710 → 779
    Ig; Immunoglobulin domain
    smart00408
    Location:90 → 157
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2174 → 2426
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:693 → 782
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:806 → 1062
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2170 → 2426
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:20 → 76
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:413 → 485
    Ig; Immunoglobulin domain

  16. XM_047442898.1 → XP_047298854.1  striated muscle preferentially expressed protein kinase isoform X11

  17. XM_005246237.3 → XP_005246294.1  striated muscle preferentially expressed protein kinase isoform X6

    Conserved Domains (8) summary
    cd00096
    Location:1408 → 1477
    Ig; Immunoglobulin domain
    smart00408
    Location:788 → 855
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2872 → 3124
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:628 → 717
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:1504 → 1760
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2868 → 3124
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:718 → 774
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:651 → 718
    Ig; Immunoglobulin domain

  18. XM_047442896.1 → XP_047298852.1  striated muscle preferentially expressed protein kinase isoform X9

  19. XM_006712189.4 → XP_006712252.1  striated muscle preferentially expressed protein kinase isoform X7

    Conserved Domains (8) summary
    cd00096
    Location:1398 → 1467
    Ig; Immunoglobulin domain
    smart00408
    Location:778 → 845
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2862 → 3114
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:618 → 707
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:1494 → 1750
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2858 → 3114
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:708 → 764
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:641 → 708
    Ig; Immunoglobulin domain

  20. XM_047442897.1 → XP_047298853.1  striated muscle preferentially expressed protein kinase isoform X10

  21. XM_047442917.1 → XP_047298873.1  striated muscle preferentially expressed protein kinase isoform X31

  22. XM_047442919.1 → XP_047298875.1  striated muscle preferentially expressed protein kinase isoform X31

  23. XM_047442922.1 → XP_047298878.1  striated muscle preferentially expressed protein kinase isoform X32

  24. XM_047442918.1 → XP_047298874.1  striated muscle preferentially expressed protein kinase isoform X31

  25. XM_047442921.1 → XP_047298877.1  striated muscle preferentially expressed protein kinase isoform X32

  26. XM_047442920.1 → XP_047298876.1  striated muscle preferentially expressed protein kinase isoform X31

  27. XM_047442923.1 → XP_047298879.1  striated muscle preferentially expressed protein kinase isoform X32

  28. XM_047442904.1 → XP_047298860.1  striated muscle preferentially expressed protein kinase isoform X21

  29. XM_047442908.1 → XP_047298864.1  striated muscle preferentially expressed protein kinase isoform X25

  30. XM_047442907.1 → XP_047298863.1  striated muscle preferentially expressed protein kinase isoform X24

  31. XM_047442912.1 → XP_047298868.1  striated muscle preferentially expressed protein kinase isoform X29

  32. XM_047442910.1 → XP_047298866.1  striated muscle preferentially expressed protein kinase isoform X27

  33. XM_047442905.1 → XP_047298861.1  striated muscle preferentially expressed protein kinase isoform X22

    UniProtKB/TrEMBL
    B9ZVR7
    Related
    ENSP00000379926.1, ENST00000396698.5

  34. XM_047442909.1 → XP_047298865.1  striated muscle preferentially expressed protein kinase isoform X26

  35. XM_047442914.1 → XP_047298870.1  striated muscle preferentially expressed protein kinase isoform X30

  36. XM_047442911.1 → XP_047298867.1  striated muscle preferentially expressed protein kinase isoform X28

  37. XM_047442900.1 → XP_047298856.1  striated muscle preferentially expressed protein kinase isoform X11

    Related
    ENST00000485813.5

  38. XM_006712193.4 → XP_006712256.1  striated muscle preferentially expressed protein kinase isoform X14

    See identical proteins and their annotated locations for XP_006712256.1

    Conserved Domains (7) summary
    cd00096
    Location:653 → 722
    Ig; Immunoglobulin domain
    smart00408
    Location:33 → 100
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2117 → 2369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:636 → 725
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:749 → 1005
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2113 → 2369
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cl11960
    Location:356 → 428
    Ig; Immunoglobulin domain

  39. XM_005246240.2 → XP_005246297.1  striated muscle preferentially expressed protein kinase isoform X14

    See identical proteins and their annotated locations for XP_005246297.1

    Conserved Domains (7) summary
    cd00096
    Location:653 → 722
    Ig; Immunoglobulin domain
    smart00408
    Location:33 → 100
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2117 → 2369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:636 → 725
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:749 → 1005
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2113 → 2369
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cl11960
    Location:356 → 428
    Ig; Immunoglobulin domain

  40. XM_005246241.2 → XP_005246298.1  striated muscle preferentially expressed protein kinase isoform X14

    See identical proteins and their annotated locations for XP_005246298.1

    Conserved Domains (7) summary
    cd00096
    Location:653 → 722
    Ig; Immunoglobulin domain
    smart00408
    Location:33 → 100
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2117 → 2369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:636 → 725
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:749 → 1005
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2113 → 2369
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cl11960
    Location:356 → 428
    Ig; Immunoglobulin domain

  41. XM_005246242.5 → XP_005246299.1  striated muscle preferentially expressed protein kinase isoform X13

    Conserved Domains (8) summary
    cd00096
    Location:715 → 784
    Ig; Immunoglobulin domain
    smart00408
    Location:95 → 162
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:2179 → 2431
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam07679
    Location:698 → 787
    I-set; Immunoglobulin I-set domain
    cd14108
    Location:811 → 1067
    STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    cd14111
    Location:2175 → 2431
    STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
    pfam16650
    Location:27 → 81
    SPEG_u2; Unstructured region on SPEG complex protein
    cl11960
    Location:418 → 490
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219919623..219978369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340134.1 → XP_054196109.1  striated muscle preferentially expressed protein kinase isoform X2

  2. XM_054340133.1 → XP_054196108.1  striated muscle preferentially expressed protein kinase isoform X1

  3. XM_054340136.1 → XP_054196111.1  striated muscle preferentially expressed protein kinase isoform X4

  4. XM_054340135.1 → XP_054196110.1  striated muscle preferentially expressed protein kinase isoform X3

  5. XM_054340137.1 → XP_054196112.1  striated muscle preferentially expressed protein kinase isoform X5

  6. XM_054340140.1 → XP_054196115.1  striated muscle preferentially expressed protein kinase isoform X8

  7. XM_054340145.1 → XP_054196120.1  striated muscle preferentially expressed protein kinase isoform X12

  8. XM_054340151.1 → XP_054196126.1  striated muscle preferentially expressed protein kinase isoform X15

  9. XM_054340152.1 → XP_054196127.1  striated muscle preferentially expressed protein kinase isoform X16

  10. XM_054340153.1 → XP_054196128.1  striated muscle preferentially expressed protein kinase isoform X17

  11. XM_054340155.1 → XP_054196130.1  striated muscle preferentially expressed protein kinase isoform X19

  12. XM_054340154.1 → XP_054196129.1  striated muscle preferentially expressed protein kinase isoform X18

  13. XM_054340159.1 → XP_054196134.1  striated muscle preferentially expressed protein kinase isoform X23

  14. XM_054340156.1 → XP_054196131.1  striated muscle preferentially expressed protein kinase isoform X20

  15. XM_054340138.1 → XP_054196113.1  striated muscle preferentially expressed protein kinase isoform X6

  16. XM_054340169.1 → XP_054196144.1  striated muscle preferentially expressed protein kinase isoform X31

  17. XM_054340168.1 → XP_054196143.1  striated muscle preferentially expressed protein kinase isoform X31

  18. XM_054340161.1 → XP_054196136.1  striated muscle preferentially expressed protein kinase isoform X25

  19. XM_054340165.1 → XP_054196140.1  striated muscle preferentially expressed protein kinase isoform X29

  20. XM_054340172.1 → XP_054196147.1  striated muscle preferentially expressed protein kinase isoform X32

  21. XM_054340144.1 → XP_054196119.1  striated muscle preferentially expressed protein kinase isoform X11

  22. XM_054340143.1 → XP_054196118.1  striated muscle preferentially expressed protein kinase isoform X11

  23. XM_054340141.1 → XP_054196116.1  striated muscle preferentially expressed protein kinase isoform X9

  24. XM_054340139.1 → XP_054196114.1  striated muscle preferentially expressed protein kinase isoform X7

  25. XM_054340142.1 → XP_054196117.1  striated muscle preferentially expressed protein kinase isoform X10

  26. XM_054340158.1 → XP_054196133.1  striated muscle preferentially expressed protein kinase isoform X22

    UniProtKB/TrEMBL
    B9ZVR7

  27. XM_054340167.1 → XP_054196142.1  striated muscle preferentially expressed protein kinase isoform X31

  28. XM_054340171.1 → XP_054196146.1  striated muscle preferentially expressed protein kinase isoform X32

  29. XM_054340170.1 → XP_054196145.1  striated muscle preferentially expressed protein kinase isoform X31

  30. XM_054340173.1 → XP_054196148.1  striated muscle preferentially expressed protein kinase isoform X32

  31. XM_054340157.1 → XP_054196132.1  striated muscle preferentially expressed protein kinase isoform X21

  32. XM_054340160.1 → XP_054196135.1  striated muscle preferentially expressed protein kinase isoform X24

  33. XM_054340163.1 → XP_054196138.1  striated muscle preferentially expressed protein kinase isoform X27

  34. XM_054340162.1 → XP_054196137.1  striated muscle preferentially expressed protein kinase isoform X26

  35. XM_054340166.1 → XP_054196141.1  striated muscle preferentially expressed protein kinase isoform X30

  36. XM_054340164.1 → XP_054196139.1  striated muscle preferentially expressed protein kinase isoform X28

  37. XM_054340146.1 → XP_054196121.1  striated muscle preferentially expressed protein kinase isoform X11

  38. XM_054340150.1 → XP_054196125.1  striated muscle preferentially expressed protein kinase isoform X14

  39. XM_054340148.1 → XP_054196123.1  striated muscle preferentially expressed protein kinase isoform X14

  40. XM_054340149.1 → XP_054196124.1  striated muscle preferentially expressed protein kinase isoform X14

  41. XM_054340147.1 → XP_054196122.1  striated muscle preferentially expressed protein kinase isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15772.4 GenPept UniProtKB/Swiss-Prot:Q15772

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