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DLEU1 deleted in lymphocytic leukemia 1 [ Homo sapiens (human) ]

Gene ID: 10301, updated on 22-Oct-2024

Summary

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Official Symbol
DLEU1provided by HGNC
Official Full Name
deleted in lymphocytic leukemia 1provided by HGNC
Primary source
HGNC:HGNC:13747
See related
Ensembl:ENSG00000176124 MIM:605765; AllianceGenome:HGNC:13747
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCMS; DLB1; LEU1; LEU2; XTP6; BCMS1; DLEU2; LINC00021; NCRNA00021
Expression
Ubiquitous expression in testis (RPKM 1.6), colon (RPKM 1.5) and 25 other tissues See more
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Genomic context

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See DLEU1 in Genome Data Viewer
Location:
13q14.2-q14.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50082169..50528643)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49302750..49743563)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50656305..51102779)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50656434-50657229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7759 Neighboring gene Sharpr-MPRA regulatory region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5353 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene NANOG hESC enhancer GRCh37_chr13:50695956-50696481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50699798-50700508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5359 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50715020-50715693 Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7760 Neighboring gene uncharacterized LOC124900337 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:50818353-50819552 Neighboring gene NANOG hESC enhancer GRCh37_chr13:50823191-50823706 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50850586-50851108 Neighboring gene Sharpr-MPRA regulatory region 6827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50952541-50953137 Neighboring gene ribosomal protein L34 pseudogene 26 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:51102968-51104167 Neighboring gene DLEU1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7762 Neighboring gene Sharpr-MPRA regulatory region 8262 Neighboring gene uncharacterized LOC107984568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7766 Neighboring gene deleted in lymphocytic leukemia 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7768 Neighboring gene DLEU7 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma]. Zhang JJ, et al. Zhongguo Gu Shang, 2023 Jun 25. PMID 37366099
  2. LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis. Sun KD, et al. Kaohsiung J Med Sci, 2022 Oct. PMID 36039933
  3. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. Wolf S, et al. Hum Mol Genet, 2001 Jun 1. PMID 11406609
  4. The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL. Lee S, et al. Oncotarget, 2017 Apr 25. PMID 28427156, Free PMC Article
  5. Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer. Dong A, et al. Mol Med Rep, 2022 Mar. PMID 35014679, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA DLEU1 promotes angiogenesis in diabetic foot ulcer wound healing by regulating miR-96-5p.
    Title: LncRNA DLEU1 promotes angiogenesis in diabetic foot ulcer wound healing by regulating miR-96-5p.
  2. [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma].
    Title: [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma].
  3. Overexpression of lncRNA DLEU1 in Gastric Cancer Tissues Compared to Adjacent Non-Tumor Tissues.
    Title: Overexpression of lncRNA DLEU1 in Gastric Cancer Tissues Compared to Adjacent Non-Tumor Tissues.
  4. LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis.
    Title: LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis.
  5. YY1-induced DLEU1/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1/TEAD2/SOX2.
    Title: YY1-induced DLEU1/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1/TEAD2/SOX2.
  6. Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
    Title: Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2.
  7. lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p.
    Title: lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p.
  8. DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma.
    Title: DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma.
  9. Survivalrelated DLEU1 is associated with HPV infection status and serves as a biomarker in HPVinfected cervical cancer.
    Title: Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer.
  10. LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.
    Title: LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
EBI GWAS Catalog
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
EBI GWAS Catalog
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • B-cell neoplasia-associated gene with multiple splicing
  • deleted in lymphocytic leukemia 1 (non-protein coding)
  • leukemia-associated protein 2
  • long intergenic non-protein coding RNA 21

Clone Names

  • FLJ92453, MGC22430

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002605.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL137060
    Related
    ENST00000655550.2

  2. NR_109973.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AJ412024, AK095311, AL137060, DB444728
    Related
    ENST00000469754.4

  3. NR_109974.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains multiple additional 3' terminal exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AJ412032, AJ412055, AL161424, DB444728
    Related
    ENST00000491615.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    50082169..50528643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    49302750..49743563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005887.1: Suppressed sequence

    Description
    NM_005887.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

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