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Ttc41 tetratricopeptide repeat domain 41 [ Mus musculus (house mouse) ]

Gene ID: 103220, updated on 2-Nov-2024

Summary

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Official Symbol
Ttc41provided by MGI
Official Full Name
tetratricopeptide repeat domain 41provided by MGI
Primary source
MGI:MGI:2387653
See related
Ensembl:ENSMUSG00000044937 AllianceGenome:MGI:2387653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnn
Summary
Predicted to be located in cytoplasm. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TTC41P (tetratricopeptide repeat domain 41, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 105.6), testis adult (RPKM 7.9) and 1 other tissue See more
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Genomic context

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See Ttc41 in Genome Data Viewer
Location:
10 C1; 10 43.07 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86541675..86612708)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86705811..86776844)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810014B01 gene Neighboring gene STARR-seq mESC enhancer starr_27467 Neighboring gene heat shock protein 90, beta (Grp94), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8356 Neighboring gene stabilin 2 Neighboring gene STARR-seq mESC enhancer starr_27475 Neighboring gene ADNP homeobox 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia. van den Akker E, et al. J Virol, 2005 May. PMID 15827139, Free PMC Article
  2. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Ruiz S, et al. Development, 2003 Jun. PMID 12702649
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC40847

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 41
Names
TPR repeat protein 41
TPR repeat protein GNN
grp94-neighboring nucleotidase
tetratricopeptide repeat protein GNN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003910.2 → NP_001003910.2  tetratricopeptide repeat protein 41 isoform 3

    See identical proteins and their annotated locations for NP_001003910.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and it encodes the longest protein (isoform 3).
    Source sequence(s)
    AC152453, AK133195, AK166553, BG072108
    Consensus CDS
    CCDS24098.1
    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Related
    ENSMUSP00000075059.7, ENSMUST00000075632.14
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  2. NM_001003939.2 → NP_001003939.2  tetratricopeptide repeat protein 41 isoform 1

    See identical proteins and their annotated locations for NP_001003939.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 3. These differences result in a protein (isoform 1) with a shorter C-terminus compared to isoform 3.
    Source sequence(s)
    AC152453, BC030307
    Consensus CDS
    CCDS24099.1
    UniProtKB/TrEMBL
    A0A0G2LB92
    Related
    ENSMUSP00000062844.8, ENSMUST00000061458.9

  3. NM_153595.3 → NP_705823.3  tetratricopeptide repeat protein 41 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 3. These differences result in a protein (isoform 2) with a shorter C-terminus compared to isoform 3.
    Source sequence(s)
    AC152453
    Consensus CDS
    CCDS88066.1
    UniProtKB/TrEMBL
    A0A1W2P894
    Related
    ENSMUSP00000151920.2, ENSMUST00000219108.2
    Conserved Domains (2) summary
    smart00382
    Location:336 → 443
    AAA; ATPases associated with a variety of cellular activities
    cl21455
    Location:336 → 443
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    86541675..86612708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512995.4 → XP_006513058.1  tetratricopeptide repeat protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006513058.1

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  2. XM_006512997.4 → XP_006513060.1  tetratricopeptide repeat protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006513060.1

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  3. XM_006512996.4 → XP_006513059.1  tetratricopeptide repeat protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006513059.1

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  4. XM_006513005.4 → XP_006513068.1  tetratricopeptide repeat protein 41 isoform X6

  5. XM_006513000.5 → XP_006513063.1  tetratricopeptide repeat protein 41 isoform X2

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  6. XM_006513001.5 → XP_006513064.1  tetratricopeptide repeat protein 41 isoform X3

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  7. XM_006513002.5 → XP_006513065.1  tetratricopeptide repeat protein 41 isoform X4

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5

  8. XM_006513006.5 → XP_006513069.1  tetratricopeptide repeat protein 41 isoform X8

    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  9. XM_017313758.3 → XP_017169247.1  tetratricopeptide repeat protein 41 isoform X7

    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  10. XM_006513003.5 → XP_006513066.1  tetratricopeptide repeat protein 41 isoform X5

    Conserved Domains (1) summary
    pfam13191
    Location:337 → 443
    AAA_16; AAA ATPase domain

  11. XM_036155456.1 → XP_036011349.1  tetratricopeptide repeat protein 41 isoform X11

    Conserved Domains (1) summary
    smart00382
    Location:336 → 443
    AAA; ATPases associated with a variety of cellular activities

  12. XM_011243258.4 → XP_011241560.1  tetratricopeptide repeat protein 41 isoform X10

    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  13. XM_006512998.4 → XP_006513061.1  tetratricopeptide repeat protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006513061.1

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  14. XM_006512999.4 → XP_006513062.1  tetratricopeptide repeat protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006513062.1

    UniProtKB/Swiss-Prot
    Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
    UniProtKB/TrEMBL
    F8VPV8
    Conserved Domains (1) summary
    pfam13401
    Location:336 → 443
    AAA_22; AAA domain

  15. XM_006513007.3 → XP_006513070.1  tetratricopeptide repeat protein 41 isoform X9

  16. XM_006513009.5 → XP_006513072.1  tetratricopeptide repeat protein 41 isoform X12

  17. XM_036155457.1 → XP_036011350.1  tetratricopeptide repeat protein 41 isoform X13

  18. XM_017313760.1 → XP_017169249.1  tetratricopeptide repeat protein 41 isoform X14

RNA

  1. XR_004936026.1 RNA Sequence

  2. XR_004936019.1 RNA Sequence

  3. XR_004936020.1 RNA Sequence

  4. XR_004936022.1 RNA Sequence

  5. XR_004936028.1 RNA Sequence

  6. XR_004936023.1 RNA Sequence

  7. XR_004936021.1 RNA Sequence

  8. XR_004936024.1 RNA Sequence

  9. XR_004936025.1 RNA Sequence

  10. XR_004936027.1 RNA Sequence

  11. XR_004936015.1 RNA Sequence

  12. XR_004936016.1 RNA Sequence

  13. XR_004936012.1 RNA Sequence

  14. XR_001779398.3 RNA Sequence

  15. XR_004936013.1 RNA Sequence

  16. XR_004936014.1 RNA Sequence

  17. XR_004936017.1 RNA Sequence

  18. XR_004936018.1 RNA Sequence

  19. XR_871676.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q692V3.1 GenPept UniProtKB/Swiss-Prot:Q692V3

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