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RRAGB Ras related GTP binding B [ Homo sapiens (human) ]

Gene ID: 10325, updated on 5-Mar-2024

Summary

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Official Symbol
RRAGBprovided by HGNC
Official Full Name
Ras related GTP binding Bprovided by HGNC
Primary source
HGNC:HGNC:19901
See related
Ensembl:ENSG00000083750 MIM:300725; AllianceGenome:HGNC:19901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGB; bA465E19.1
Summary
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 5.3), thyroid (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xp11.21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55717749..55758774)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (55010926..55051952)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55744182..55785207)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene ReSE screen-validated silencer GRCh37_chrX:55700255-55700456 Neighboring gene XAGE-4 protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29684 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:55945424-55946623 Neighboring gene KLF transcription factor 8 Neighboring gene GOT2 pseudogene 6 Neighboring gene uncharacterized LOC124905192

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop. Li X, et al. Mol Cancer, 2022 Jun 23. PMID 35739524, Free PMC Article
  2. Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma. Xiao J, et al. Bioengineered, 2021 Dec. PMID 34320917, Free PMC Article
  3. Glutaminolysis activates Rag-mTORC1 signaling. Durán RV, et al. Mol Cell, 2012 Aug 10. PMID 22749528
  4. Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression. Shi Y, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34482023
  5. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1). Shibutani S, et al. J Biol Chem, 2017 Nov 3. PMID 28808055, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
    Title: circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
  2. Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
    Title: Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
  3. Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma.
    Title: Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma.
  4. Data suggest DNM2/RRAGB- (or DNM2/RRAGC-)dependent endocytosis of extracellular amino acids (AAs) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB = Ras homolog enriched in brain; DNM2 = dynamin II; RRAG = Ras-related GTP binding protein)
    Title: Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).
  5. Inhibition of glutaminolysis prevents GTP loading of RagB and lysosomal translocation and subsequent activation of mTORC1.
    Title: Glutaminolysis activates Rag-mTORC1 signaling.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of Ras-related GTP binding B (RRAGB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl ribonucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to leucine starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in lysosomal membrane HDA PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related GTP-binding protein B
Names
GTP-binding protein ragB
rag B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354011.2 → NP_001340940.1  ras-related GTP-binding protein B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
    Conserved Domains (1) summary
    cd11384
    Location:4 → 315
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  2. NM_001354013.2 → NP_001340942.1  ras-related GTP-binding protein B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
    Conserved Domains (1) summary
    cd11384
    Location:4 → 287
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  3. NM_006064.5 → NP_006055.3  ras-related GTP-binding protein B short isoform

    See identical proteins and their annotated locations for NP_006055.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as RAGBs) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter isoform (2).
    Source sequence(s)
    BC034726, DB252202
    Consensus CDS
    CCDS14371.1
    UniProtKB/Swiss-Prot
    Q5VZM2
    Related
    ENSP00000364077.4, ENST00000374941.9
    Conserved Domains (1) summary
    cd11384
    Location:42 → 325
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  4. NM_016656.4 → NP_057740.2  ras-related GTP-binding protein B long isoform

    See identical proteins and their annotated locations for NP_057740.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as RAGBl) encodes the longest isoform (1).
    Source sequence(s)
    BC034726, DB252202, X90530
    Consensus CDS
    CCDS14372.1
    UniProtKB/Swiss-Prot
    A8K042, Q15348, Q5VZM2, Q8N3T0
    Related
    ENSP00000262850.7, ENST00000262850.7
    Conserved Domains (1) summary
    cd11384
    Location:42 → 353
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RNA

  1. NR_148683.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  2. NR_148684.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  3. NR_148685.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  4. NR_148686.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  5. NR_148687.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  6. NR_148688.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  7. NR_148689.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  8. NR_148690.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  9. NR_148691.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

  10. NR_148692.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55717749..55758774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029218.3 → XP_016884707.1  ras-related GTP-binding protein B isoform X1

  2. XM_047441764.1 → XP_047297720.1  ras-related GTP-binding protein B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    55010926..55051952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326364.1 → XP_054182339.1  ras-related GTP-binding protein B isoform X1

RNA

  1. XR_008485448.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZM2.1 GenPept UniProtKB/Swiss-Prot:Q5VZM2

Gene LinkOut

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Chemical Information
Molecular Biology Databases
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