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MIR8485 microRNA 8485 [ Homo sapiens (human) ]

Gene ID: 103504737, updated on 17-Sep-2024

Summary

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Official Symbol
MIR8485provided by HGNC
Official Full Name
microRNA 8485provided by HGNC
Primary source
HGNC:HGNC:50839
See related
Ensembl:ENSG00000216191 miRBase:MI0027288; AllianceGenome:HGNC:50839
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hsa-mir-8485
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR8485 in Genome Data Viewer
Location:
2p16.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (50696172..50696262, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (50692343..50692429, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (50923310..50923400, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene neurexin 1 Neighboring gene MPRA-validated peak3699 silencer Neighboring gene VISTA enhancer hs1348 Neighboring gene uncharacterized LOC101927089 Neighboring gene MT-CO1 pseudogene 42 Neighboring gene uncharacterized LOC124906006 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:51227905-51228438 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:51240083-51240639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:51254469-51255168 Neighboring gene NRXN1 divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:51483602-51484801 Neighboring gene uncharacterized LOC105377627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs. Li Z, et al. Biochem Biophys Res Commun, 2020 Mar 5. PMID 31898972
  2. Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions. Li W, et al. Int J Oncol, 2019 May. PMID 30896790, Free PMC Article
  3. Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression. Fan Z, et al. Genomics, 2014 Jan. PMID 23827811
  4. miR-8485 alleviates the injury of cardiomyocytes through TP53INP1. Luo X, et al. J Biochem Mol Toxicol, 2022 Oct. PMID 35876212
  5. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
    Title: miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
  2. Chondrocytes-derived exosomal miR-8485 regulated the Wnt/beta-catenin pathways to promote chondrogenic differentiation of BMSCs.
    Title: Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs.
  3. miR8485 was identified to be ectopically expressed. The exosomal miR8485 was capable of promoting the proliferation, migration and invasion of oral tumors. Study highlights the significance of mesenchymal stem cellsderived exosomes and exosomal miR8485 in premalignant lesions and carcinogenesis.
    Title: Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions.
  4. miR-NID1 represses NRXN1 expression by binding to TDP-43.
    Title: Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_130470.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC009234
    Related
    ENST00000401372.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    50696172..50696262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    50692343..50692429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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