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Pnpo pyridoxine 5'-phosphate oxidase [ Mus musculus (house mouse) ]

Gene ID: 103711, updated on 2-Nov-2024

Summary

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Official Symbol
Pnpoprovided by MGI
Official Full Name
pyridoxine 5'-phosphate oxidaseprovided by MGI
Primary source
MGI:MGI:2144151
See related
Ensembl:ENSMUSG00000018659 AllianceGenome:MGI:2144151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables pyridoxamine phosphate oxidase activity. Involved in pyridoxal phosphate metabolic process and pyridoxamine metabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14.5 (RPKM 227.8), liver E14 (RPKM 217.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Pnpo in Genome Data Viewer
Location:
11 D; 11 60.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96828642..96834845, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96937816..96944019, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E202 Neighboring gene predicted gene 11525 Neighboring gene proline rich 15-like Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene Sp2 transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vitamin B6 Addiction in Acute Myeloid Leukemia. Chen CC, et al. Cancer Cell, 2020 Jan 13. PMID 31935373, Free PMC Article
  2. Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase. Kang JH, et al. Eur J Biochem, 2004 Jun. PMID 15182361
  3. Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNA. Ngo EO, et al. Biochemistry, 1998 May 26. PMID 9601034
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxamine phosphate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxamine phosphate oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxamine phosphate oxidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables pyridoxamine phosphate oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in pyridoxal phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxal phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridoxal phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyridoxal phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyridoxamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyridoxine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pyridoxine-5'-phosphate oxidase
Names
pyridoxamine-phosphate oxidase
NP_598782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134021.2 → NP_598782.1  pyridoxine-5'-phosphate oxidase

    See identical proteins and their annotated locations for NP_598782.1

    Status: VALIDATED

    Source sequence(s)
    AI464320, AK164667, AL596384, CK625276
    Consensus CDS
    CCDS25308.1
    UniProtKB/Swiss-Prot
    Q3TP70, Q3U445, Q3U4X1, Q91XF0
    Related
    ENSMUSP00000018803.6, ENSMUST00000018803.12
    Conserved Domains (3) summary
    TIGR00558
    Location:57 → 261
    pdxH; pyridoxamine-phosphate oxidase
    pfam01243
    Location:75 → 153
    Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
    pfam10590
    Location:206 → 261
    PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96828642..96834845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XF0.1 GenPept UniProtKB/Swiss-Prot:Q91XF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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