Tmem98 transmembrane protein 98 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem98provided by MGI
Official Full Name: transmembrane protein 98provided by MGI
Primary source: MGI:MGI:1923457
See related: Ensembl:ENSMUSG00000035413 AllianceGenome:MGI:1923457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rwhs; 6530411B15Rik
Summary: Involved in several processes, including T-helper 1 cell differentiation; negative regulation of protein processing; and regulation of nervous system development. Located in endoplasmic reticulum membrane and extracellular space. Is expressed in pigmented retinal epithelium; spinal cord; and white matter. Human ortholog(s) of this gene implicated in nanophthalmos. Orthologous to human TMEM98 (transmembrane protein 98). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in large intestine adult (RPKM 90.9), duodenum adult (RPKM 84.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 B5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (80701192..80712859)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (80810366..80822033)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypic consequences of a nanophthalmos-associated TMEM98 variant in human and mouse.
Title: Phenotypic consequences of a nanophthalmos-associated TMEM98 variant in human and mouse.
findings highlight the importance of the interplay between TMEM98 and MYRF in determining the size of the eye
Title: The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
TMEM98 reduces FRAT2 protein levels and, accordingly, inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling.
Title: TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling.
TMEM98 membrane protein physically interacts with MYRF in the endoplasmic reticulum and subsequently blocks its self-cleavage.
Title: Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm168 (e-PCR), detects polymorphism
- UniSTS:141606

AI463522 (e-PCR)
- UniSTS:180271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 1 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane protein 98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.