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Tubg2 tubulin, gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 103768, updated on 2-Nov-2024

Summary

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Official Symbol
Tubg2provided by MGI
Official Full Name
tubulin, gamma 2provided by MGI
Primary source
MGI:MGI:2144208
See related
Ensembl:ENSMUSG00000045007 AllianceGenome:MGI:2144208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tubgl
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in cytoplasmic microtubule; pericentriolar material; and spindle microtubule. Is expressed in several structures, including head mesenchyme; heart; nervous system; sensory organ epithelium; and tooth. Orthologous to human TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 14.5), cortex adult (RPKM 14.3) and 25 other tissues See more
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Genomic context

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See Tubg2 in Genome Data Viewer
Location:
11 D; 11 64.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101045945..101052613)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101155874..101161787)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene knockout analysis of two gamma-tubulin isoforms in mice. Yuba-Kubo A, et al. Dev Biol, 2005 Jun 15. PMID 15893303
  2. Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte. Barrett SL, et al. Biol Reprod, 2007 Jun. PMID 17287496
  3. MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages. Eng EW, et al. Mol Biol Cell, 2007 Jul. PMID 17442887, Free PMC Article
  4. γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. Vinopal S, et al. PLoS One, 2012. PMID 22235350, Free PMC Article
  5. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. Leonard PH, et al. BMC Dev Biol, 2015 May 29. PMID 26021315, Free PMC Article

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gamma-tubulin 2 is able to nucleate microtubules and substitute for gamma-tubulin 1
    Title: γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tubulin gamma-2 chain
Names
gamma-2-tubulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134028.2 → NP_598789.1  tubulin gamma-2 chain

    See identical proteins and their annotated locations for NP_598789.1

    Status: VALIDATED

    Source sequence(s)
    AL590969
    Consensus CDS
    CCDS25452.1
    UniProtKB/Swiss-Prot
    Q8VCK3
    UniProtKB/TrEMBL
    Q6F4J0
    Related
    ENSMUSP00000045901.10, ENSMUST00000043654.10
    Conserved Domains (1) summary
    cd02188
    Location:3 → 435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101045945..101052613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531917.4 → XP_006531980.1  tubulin gamma-2 chain isoform X1

    Conserved Domains (1) summary
    cd02188
    Location:1 → 258
    gamma_tubulin; The gamma-tubulin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCK3.1 GenPept UniProtKB/Swiss-Prot:Q8VCK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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