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ANAPC10 anaphase promoting complex subunit 10 [ Homo sapiens (human) ]

Gene ID: 10393, updated on 2-Nov-2024

Summary

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Official Symbol
ANAPC10provided by HGNC
Official Full Name
anaphase promoting complex subunit 10provided by HGNC
Primary source
HGNC:HGNC:24077
See related
Ensembl:ENSG00000164162 MIM:613745; AllianceGenome:HGNC:24077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOC1; APC10
Summary
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

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See ANAPC10 in Genome Data Viewer
Location:
4q31.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (144994575..145098571, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (148311947..148415963, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (145915727..146019723, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900792 Neighboring gene uncharacterized LOC124900793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15722 Neighboring gene RN7SK pseudogene 235 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:146018722-146019921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21962 Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene OTU deubiquitinase 4 Neighboring gene MPRA-validated peak5130 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21963 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146100843-146101672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146101673-146102502 Neighboring gene uncharacterized LOC124900794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt KS, et al. Nat Struct Biol, 2001 Sep. PMID 11524682
  2. A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer. Wang Y, et al. Cell Cycle, 2019 May. PMID 31023143, Free PMC Article
  3. Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. Kurasawa Y, et al. Oncogene, 1999 Sep 16. PMID 10498862
  4. The APC10 subunit of the anaphase-promoting complex/cyclosome orchestrates NLRP3 inflammasome activation during the cell cycle. Huang S, et al. FEBS Lett, 2021 Oct. PMID 34407203
  5. Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. Nourry C, et al. BMC Cell Biol, 2004 May 16. PMID 15144564, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APC10 was overexpressed in non-small cell lung cancer cell lines compared to human bronchial epithelial cell lines. APC10 was shown to interact with GAC; knocking down APC10 downregulated glutamine metabolism to induce autophagy, resulting in effective inhibition of the proliferation and migration of non-small cell lung cancer cells.
    Title: A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
  2. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
    Title: How APC/C-Cdc20 changes its substrate specificity in mitosis.
  3. Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1.
    Title: Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564L0562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein branched polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 10
Names
cyclosome subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256706.2 → NP_001243635.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC097649, AF132794, AL080090, BF693880, BU175327
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
    UniProtKB/TrEMBL
    D6RA92
    Related
    ENSP00000423995.1, ENST00000507656.6
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  2. NM_001256707.2 → NP_001243636.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC097649, AL080090, BF693880, CV023091
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
    UniProtKB/TrEMBL
    D6RA92
    Related
    ENSP00000403891.2, ENST00000451299.6
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  3. NM_001256708.2 → NP_001243637.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC096757, AC097649, BU567906, CV023091
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
    UniProtKB/TrEMBL
    D6RA92
    Related
    ENSP00000478501.1, ENST00000613466.4
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  4. NM_001256709.2 → NP_001243638.1  anaphase-promoting complex subunit 10 isoform 2

    See identical proteins and their annotated locations for NP_001243638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AL080090, BF693880, BG494966
    UniProtKB/TrEMBL
    D6RA92
    Conserved Domains (1) summary
    pfam03256
    Location:15 → 194
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  5. NM_001256710.2 → NP_001243639.1  anaphase-promoting complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_001243639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AL080090, BF693880, CN305215
    UniProtKB/TrEMBL
    A0A3B3ISY7
    Related
    ENSP00000423223.1, ENST00000504721.5
    Conserved Domains (1) summary
    cl02148
    Location:4 → 109
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  6. NM_001256711.2 → NP_001243640.1  anaphase-promoting complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_001243640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, BF693880, BG530912, CN305215
    UniProtKB/TrEMBL
    A0A3B3ISY7
    Conserved Domains (1) summary
    cl02148
    Location:4 → 109
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  7. NM_001256712.2 → NP_001243641.1  anaphase-promoting complex subunit 10 isoform 4

    See identical proteins and their annotated locations for NP_001243641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AV757106, BF693880
    UniProtKB/TrEMBL
    D6RB36
    Conserved Domains (1) summary
    cl02148
    Location:4 → 69
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  8. NM_001318367.2 → NP_001305296.1  anaphase-promoting complex subunit 10 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate 5' terminal exon compared to variant 1. This difference results in a distinct 5' UTR, translation initiation at an alternate start codon, and a novel 5' coding region compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB012109, AC096757, AC097649, AW025455, BI913723
    UniProtKB/Swiss-Prot
    Q9UM13
    Conserved Domains (1) summary
    pfam03256
    Location:38 → 217
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  9. NM_014885.5 → NP_055700.2  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_055700.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AB012109, AC097649
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
    UniProtKB/TrEMBL
    D6RA92
    Related
    ENSP00000310071.5, ENST00000309439.9
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

RNA

  1. NR_046345.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC097649, BF693880, BI488888

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    144994575..145098571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531531.4 → XP_011529833.2  anaphase-promoting complex subunit 10 isoform X8

    Related
    ENSP00000424463.1, ENST00000502847.1

  2. XM_047449503.1 → XP_047305459.1  anaphase-promoting complex subunit 10 isoform X2

  3. XM_047449507.1 → XP_047305463.1  anaphase-promoting complex subunit 10 isoform X9

  4. XM_047449502.1 → XP_047305458.1  anaphase-promoting complex subunit 10 isoform X1

  5. XM_047449504.1 → XP_047305460.1  anaphase-promoting complex subunit 10 isoform X2

  6. XM_017007639.3 → XP_016863128.1  anaphase-promoting complex subunit 10 isoform X1

    Conserved Domains (1) summary
    pfam03256
    Location:38 → 217
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

  7. XM_011531525.3 → XP_011529827.2  anaphase-promoting complex subunit 10 isoform X3

  8. XM_017007642.2 → XP_016863131.1  anaphase-promoting complex subunit 10 isoform X6

  9. XM_017007641.2 → XP_016863130.1  anaphase-promoting complex subunit 10 isoform X4

  10. XM_047449505.1 → XP_047305461.1  anaphase-promoting complex subunit 10 isoform X5

    UniProtKB/TrEMBL
    D6RD74
    Related
    ENSP00000425459.1, ENST00000512680.5

  11. XM_047449506.1 → XP_047305462.1  anaphase-promoting complex subunit 10 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    148311947..148415963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348736.1 → XP_054204711.1  anaphase-promoting complex subunit 10 isoform X8

  2. XM_054348729.1 → XP_054204704.1  anaphase-promoting complex subunit 10 isoform X2

  3. XM_054348737.1 → XP_054204712.1  anaphase-promoting complex subunit 10 isoform X9

  4. XM_054348727.1 → XP_054204702.1  anaphase-promoting complex subunit 10 isoform X1

  5. XM_054348730.1 → XP_054204705.1  anaphase-promoting complex subunit 10 isoform X2

  6. XM_054348728.1 → XP_054204703.1  anaphase-promoting complex subunit 10 isoform X1

  7. XM_054348731.1 → XP_054204706.1  anaphase-promoting complex subunit 10 isoform X3

  8. XM_054348734.1 → XP_054204709.1  anaphase-promoting complex subunit 10 isoform X6

  9. XM_054348732.1 → XP_054204707.1  anaphase-promoting complex subunit 10 isoform X4

  10. XM_054348733.1 → XP_054204708.1  anaphase-promoting complex subunit 10 isoform X5

    UniProtKB/TrEMBL
    D6RD74

  11. XM_054348735.1 → XP_054204710.1  anaphase-promoting complex subunit 10 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UM13.1 GenPept UniProtKB/Swiss-Prot:Q9UM13

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