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Adcy3 adenylate cyclase 3 [ Mus musculus (house mouse) ]

Gene ID: 104111, updated on 2-Nov-2024

Summary

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Official Symbol
Adcy3provided by MGI
Official Full Name
adenylate cyclase 3provided by MGI
Primary source
MGI:MGI:99675
See related
Ensembl:ENSMUSG00000020654 AllianceGenome:MGI:99675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC3; ACIII; mKIAA0511
Summary
Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 11.6), ovary adult (RPKM 9.6) and 24 other tissues See more
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Genomic context

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See Adcy3 in Genome Data Viewer
Location:
12 A1.1; 12 1.99 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4183397..4263525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4133116..4213525)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:3981365-3981666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3982390-3982573 Neighboring gene EFR3 homolog B Neighboring gene STARR-seq mESC enhancer starr_31433 Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene predicted gene, 53749 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
    Title: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
  2. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
    Title: Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice.
  3. Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
    Title: Adenylyl cyclase 3 deficiency results in dysfunction of blood-testis barrier during mouse spermiogenesis.
  4. Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
    Title: Adenylyl cyclase 3 regulates osteocyte mechanotransduction and primary cilium.
  5. Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
    Title: Type 3 adenylyl cyclase in the MOE is involved in learning and memory in mice.
  6. Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
    Title: Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
  7. Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons.
    Title: Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
  8. Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice.
    Title: Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice.
  9. AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE.
    Title: Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice.
  10. genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose
    Title: Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of smell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 3
Names
AC-III
ATP pyrophosphate-lyase 3
adenylate cyclase type III
adenylate cyclase, olfactive type
adenylyl cyclase 3
NP_001153008.1
NP_001153009.1
NP_001409715.1
NP_612178.2
XP_006514997.1
XP_006514998.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159536.1 → NP_001153008.1  adenylate cyclase type 3 isoform 2

    See identical proteins and their annotated locations for NP_001153008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK122298, CF532558
    Consensus CDS
    CCDS49017.1
    UniProtKB/TrEMBL
    B8JK56, Q6PGC0
    Related
    ENSMUSP00000122073.2, ENSMUST00000124505.8
    Conserved Domains (3) summary
    smart00044
    Location:883 → 1101
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. NM_001159537.1 → NP_001153009.1  adenylate cyclase type 3 isoform 2

    See identical proteins and their annotated locations for NP_001153009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2) compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK122298, CF532558
    Consensus CDS
    CCDS49017.1
    UniProtKB/TrEMBL
    B8JK56, Q6PGC0
    Related
    ENSMUSP00000115644.2, ENSMUST00000152065.8
    Conserved Domains (3) summary
    smart00044
    Location:883 → 1101
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  3. NM_001422786.1 → NP_001409715.1  adenylate cyclase type 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT572999
    UniProtKB/Swiss-Prot
    B8JK57, Q8VHH7
    Related
    ENSMUST00000152792.8

  4. NM_138305.4 → NP_612178.2  adenylate cyclase type 3 isoform 1

    See identical proteins and their annotated locations for NP_612178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CT572999
    Consensus CDS
    CCDS25787.1
    UniProtKB/Swiss-Prot
    B8JK57, Q8VHH7
    UniProtKB/TrEMBL
    Q6PGC0
    Conserved Domains (2) summary
    pfam00211
    Location:915 → 1122
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4183397..4263525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514934.5 → XP_006514997.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006514997.1

    UniProtKB/Swiss-Prot
    B8JK57, Q8VHH7
    UniProtKB/TrEMBL
    Q6PGC0
    Related
    ENSMUSP00000020984.8, ENSMUST00000020984.9
    Conserved Domains (2) summary
    pfam00211
    Location:915 → 1122
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. XM_006514935.5 → XP_006514998.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006514998.1

    UniProtKB/Swiss-Prot
    B8JK57, Q8VHH7
    UniProtKB/TrEMBL
    Q6PGC0
    Related
    ENSMUSP00000115406.2, ENSMUST00000127756.8
    Conserved Domains (2) summary
    pfam00211
    Location:915 → 1122
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHH7.2 GenPept UniProtKB/Swiss-Prot:Q8VHH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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