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RBM14 RNA binding motif protein 14 [ Homo sapiens (human) ]

Gene ID: 10432, updated on 7-Apr-2024

Summary

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Official Symbol
RBM14provided by HGNC
Official Full Name
RNA binding motif protein 14provided by HGNC
Primary source
HGNC:HGNC:14219
See related
Ensembl:ENSG00000239306 MIM:612409; AllianceGenome:HGNC:14219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; COAA; PSP2; SYTIP1; TMEM137
Summary
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Annotation information
Note: The nomenclature TMEM137, transmembrane protein 137 was assigned to BC024260, which is now thought to represent the 3' UTR of RBM14. [15 Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66616630..66629934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66612875..66626179)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66384101..66397405)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5053 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66384051-66384984 Neighboring gene RBM14-RBM4 readthrough Neighboring gene RNA, U4 small nuclear 39, pseudogene Neighboring gene hESC enhancers GRCh37_chr11:66405625-66406338 and GRCh37_chr11:66406339-66407050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66410755-66411278 Neighboring gene MPRA-validated peak1306 silencer Neighboring gene RNA binding motif protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3600 Neighboring gene RNA binding motif protein 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66453249-66453749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66462288-66462788 Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene RNA, 7SL, cytoplasmic 12, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer. Hu Y, et al. World J Surg Oncol, 2023 Apr 14. PMID 37060064, Free PMC Article
  2. Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites. Jang Y, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32094185, Free PMC Article
  3. Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein. Beyleveld G, et al. mSphere, 2018 Nov 14. PMID 30429226, Free PMC Article
  4. RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins. Simon NE, et al. Cell Cycle, 2017 Jun 18. PMID 28426349, Free PMC Article
  5. Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. Hennig S, et al. J Cell Biol, 2015 Aug 17. PMID 26283796, Free PMC Article

See all (210) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.
    Title: NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.
  2. The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
    Title: The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops.
  3. RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.
    Title: RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.
  4. RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.
    Title: RBM14 as a novel epigenetic-activated tumor oncogene is implicated in the reprogramming of glycolysis in lung cancer.
  5. METTL3 promotes m6A hypermethylation of RBM14 via YTHDF1 leading to the progression of hepatocellular carcinoma.
    Title: METTL3 promotes m6A hypermethylation of RBM14 via YTHDF1 leading to the progression of hepatocellular carcinoma.
  6. canonical nonhomologous end joining pathway utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient repair of double-strand breaks.
    Title: Intrinsically disordered protein RBM14 plays a role in generation of RNA:DNA hybrids at double-strand break sites.
  7. The influenza A virus NS1 protein is both necessary and sufficient for RBM14 relocalization, and relocalization also requires the double-stranded RNA (dsRNA) binding capacity of NS1.
    Title: Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein.
  8. RBM14 plays crucial role in regulation of non-homologous end joining upon DNA damage.
    Title: RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins.
  9. RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion-like domain.
    Title: Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.
  10. This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1), a nuclear protein that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs
    Title: Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev The localization of RBM14 to the nuclear paraspeckles is required for RBM14 enhancement of HIV-1 Rev activity in cells PubMed
rev Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54/NRB in cells PubMed
rev Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed
Tat tat RNA binding motif protein 14 (RBM14) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
capsid gag Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough RBM14-RBM4

Readthrough gene: RBM14-RBM4, Included gene: RBM4

Homology

Clone Names

  • MGC15912, MGC31756, DKFZp779J0927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables splicing factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of response to DNA integrity checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hormone TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex TAS
Traceable Author Statement
more info
 PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein 14
Names
RRM-containing coactivator activator/modulator
SYT-interacting protein
paraspeckle protein 2
synaptotagmin-interacting protein
transmembrane protein 137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030394.1 RefSeqGene

    Range
    5049..18353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198836.2 → NP_001185765.1  RNA-binding protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001185765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (2, also known as CoAM or coactivator modulator) with a distinct and shorter C-terminus compared to isoform 1. This isoform lacks the TRBP-interacting domain, and functions as a transcriptional repressor by inhibiting the activity of isoform 1 (PMID:11443112).
    Source sequence(s)
    AF315633, AP001157
    Consensus CDS
    CCDS55772.1
    UniProtKB/TrEMBL
    A0A0S2Z567
    Related
    ENSP00000377548.3, ENST00000393979.3
    Conserved Domains (2) summary
    cd12609
    Location:79 → 146
    RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cl17169
    Location:1 → 71
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001198837.2 → NP_001185766.1  RNA-binding protein 14 isoform 3

    See identical proteins and their annotated locations for NP_001185766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (3, also known as CoAR or coactivator regulator) with a distinct and shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AP001157, DB044990, DQ294957
    Consensus CDS
    CCDS55773.1
    UniProtKB/TrEMBL
    A0A0S2Z5V2, F8WDX3
    Related
    ENSP00000386995.4, ENST00000409738.4
    Conserved Domains (1) summary
    cl17169
    Location:1 → 71
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_006328.4 → NP_006319.1  RNA-binding protein 14 isoform 1

    See identical proteins and their annotated locations for NP_006319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CoAA or coactivator activator).
    Source sequence(s)
    AK021768, AP001157, DB044990
    Consensus CDS
    CCDS8147.1
    UniProtKB/Swiss-Prot
    B0LM41, B3KMN4, D6RGD8, O75932, Q2PYN1, Q53GV1, Q68DQ9, Q96PK5, Q96PK6
    UniProtKB/TrEMBL
    A0A0S2Z4Z0
    Related
    ENSP00000311747.5, ENST00000310137.5
    Conserved Domains (4) summary
    TIGR01628
    Location:3 → 280
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    PRK13875
    Location:319 → 433
    PRK13875; conjugal transfer protein TrbL; Provisional
    cd12608
    Location:1 → 71
    RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cd12609
    Location:79 → 146
    RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66616630..66629934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66612875..66626179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032886.2: Suppressed sequence

    Description
    NM_032886.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PK6.2 GenPept UniProtKB/Swiss-Prot:Q96PK6

Gene LinkOut

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