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MCRS1 microspherule protein 1 [ Homo sapiens (human) ]

Gene ID: 10445, updated on 28-Oct-2024

Summary

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Official Symbol
MCRS1provided by HGNC
Official Full Name
microspherule protein 1provided by HGNC
Primary source
HGNC:HGNC:6960
See related
Ensembl:ENSG00000187778 MIM:609504; AllianceGenome:HGNC:6960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P78; MCRS2; MSP58; INO80Q; ICP22BP
Summary
Enables RNA binding activity and telomerase inhibitor activity. Involved in several processes, including chromatin remodeling; positive regulation of protein localization to nucleolus; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and NSL complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in heart (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MCRS1 in Genome Data Viewer
Location:
12q13.12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49558299..49568142, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49520555..49530398, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49952082..49961925, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated serine rich 2 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49846952-49847452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49873095-49873682 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49907610-49907788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932121-49932932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932933-49933742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6316 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:49936243-49937442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49941330-49942138 Neighboring gene uncharacterized LOC105369761 Neighboring gene potassium voltage-gated channel subfamily H member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49961221-49962024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6319 Neighboring gene family with sequence similarity 186 member B Neighboring gene RNA, U6 small nuclear 834, pseudogene Neighboring gene RNA polymerase II subunit K pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients. Lin W, et al. Med Oncol, 2013 Dec. PMID 23996240
  2. Downregulation of MSP58 suppresses cell proliferation in neuroblastoma cell lines. Wu L, et al. Neuroreport, 2012 Nov 14. PMID 22975844
  3. Expression of MSP58 in human colorectal cancer and its correlation with prognosis. Shi H, et al. Med Oncol, 2012 Dec. PMID 22773039, Free PMC Article
  4. MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo. Xu CS, et al. Asian Pac J Cancer Prev, 2012. PMID 22994740
  5. Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase. Wang XM, et al. Cell Signal, 2019 Jul. PMID 30953699

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.
    Title: The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.
  2. MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.
    Title: MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.
  3. This study confirmed the specific tumor suppressive activity of MCRS1 in gastric cancer proliferation, invasion and migration and suggested that it might inhibit the progression of gastric cancer through its interaction with Pkmyt1.
    Title: Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.
  4. Our data suggest that decreased expression of miR-186 in hepatocellular carcinoma is responsible for the high expression of MCRS1
    Title: miR-186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1-mediated Wnt/β-catenin signaling.
  5. Authors show that Mps1 regulates chromosome alignment through MCRS1, a spindle assembly factor that controls the dynamics of the minus end of kinetochore microtubules. Mps1 binds and phosphorylates MCRS1.
    Title: Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.
  6. Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis.
    Title: MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
  7. MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells.
    Title: Knockdown of MSP58 inhibits the proliferation and metastasis in human renal cell carcinoma cells.
  8. MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36.
    Title: Aurora-A regulates MCRS1 function during mitosis.
  9. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription.
    Title: RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription.
  10. The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001).
    Title: Expression of 58-kD Microspherule Protein (MSP58) is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41193, FLJ98622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-quadruplex RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(G) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomerase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomere lengthening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein localization to nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
microspherule protein 1
Names
58 kDa microspherule protein
INO80 complex subunit J
INO80 complex subunit Q
cell cycle-regulated factor (78 kDa)
cell cycle-regulated factor p78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012300.1 → NP_001012300.1  microspherule protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001012300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AY336730, BC011794
    Consensus CDS
    CCDS31795.1
    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENSP00000349640.4, ENST00000357123.8
    Conserved Domains (2) summary
    cd00060
    Location:358 → 458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147 → 344
    MCRS_N; N-terminal region of micro-spherule protein

  2. NM_001278341.2 → NP_001265270.1  microspherule protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001265270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 2. The resulting isoform (3) has a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, BX538079, HY078747, R66413
    Consensus CDS
    CCDS61118.1
    Related
    ENSP00000444982.1, ENST00000546244.5
    Conserved Domains (2) summary
    cd00060
    Location:154 → 254
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:1 → 140
    MCRS_N; N-terminal region of micro-spherule protein

  3. NM_006337.5 → NP_006328.2  microspherule protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006328.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' coding sequence, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    BC011794, HY078747, R66413
    Consensus CDS
    CCDS8787.1
    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8
    Related
    ENSP00000345358.4, ENST00000343810.9
    Conserved Domains (2) summary
    cd00060
    Location:345 → 445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134 → 331
    MCRS_N; N-terminal region of micro-spherule protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49558299..49568142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537760.4 → XP_011536062.2  microspherule protein 1 isoform X1

  2. XM_005268572.3 → XP_005268629.1  microspherule protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005268629.1

    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8
    Related
    ENSP00000448056.1, ENST00000550165.5
    Conserved Domains (2) summary
    cd00060
    Location:345 → 445
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:134 → 331
    MCRS_N; N-terminal region of micro-spherule protein

  3. XM_017018690.2 → XP_016874179.1  microspherule protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q96EZ8
    Related
    ENST00000551625.5
    Conserved Domains (2) summary
    cd00060
    Location:358 → 458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam13325
    Location:147 → 344
    MCRS_N; N-terminal region of micro-spherule protein

  4. XM_047428083.1 → XP_047284039.1  microspherule protein 1 isoform X4

    Related
    ENSP00000447514.1, ENST00000553173.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49520555..49530398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370773.1 → XP_054226748.1  microspherule protein 1 isoform X1

  2. XM_054370775.1 → XP_054226750.1  microspherule protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O14742, O75497, Q6VN53, Q7Z372, Q96EZ8

  3. XM_054370774.1 → XP_054226749.1  microspherule protein 1 isoform X2

  4. XM_054370776.1 → XP_054226751.1  microspherule protein 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EZ8.1 GenPept UniProtKB/Swiss-Prot:Q96EZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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