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Rars1 arginyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 104458, updated on 2-Nov-2024

Summary

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Official Symbol
Rars1provided by MGI
Official Full Name
arginyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:1914297
See related
Ensembl:ENSMUSG00000018848 AllianceGenome:MGI:1914297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rars; 2610011N19Rik; 2610037E21Rik
Summary
Enables arginine-tRNA ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 41.2), CNS E11.5 (RPKM 34.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rars1 in Genome Data Viewer
Location:
11 A4; 11 21.96 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35699207..35725355, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (35808381..35834528, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene microRNA 103-1 Neighboring gene STARR-seq mESC enhancer starr_29194 Neighboring gene pantothenate kinase 3 Neighboring gene fibrillarin-like 1 Neighboring gene STARR-seq mESC enhancer starr_29197 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene teneurin transmembrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Kim JY, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060739, Free PMC Article
  2. Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Cakir Z, et al. Mol Cell Proteomics, 2023 May. PMID 37019383, Free PMC Article
  3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
  4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables arginine binding IEA
Inferred from Electronic Annotation
more info
  
enables arginine binding ISO
Inferred from Sequence Orthology
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arginine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables arginine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arginine--tRNA ligase, cytoplasmic
Names
argRS
arginyl-tRNA synthetase, cytoplasmic
NP_080212.2
XP_036012095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025936.3 → NP_080212.2  arginine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_080212.2

    Status: VALIDATED

    Source sequence(s)
    AK076160, CB523934, CF748175
    Consensus CDS
    CCDS24544.1
    UniProtKB/Swiss-Prot
    Q3THP2, Q3TM73, Q3U8R2, Q3U930, Q5SXA8, Q8VDW1, Q9D0I9
    Related
    ENSMUSP00000018992.4, ENSMUST00000018992.4
    Conserved Domains (4) summary
    cd00671
    Location:193 → 457
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:79 → 166
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:80 → 660
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:498 → 660
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    35699207..35725355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156202.1 → XP_036012095.1  arginine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    PLN02286
    Location:8 → 588
    PLN02286; arginine-tRNA ligase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0I9.2 GenPept UniProtKB/Swiss-Prot:Q9D0I9

Gene LinkOut

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