U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TRIM38 tripartite motif containing 38 [ Homo sapiens (human) ]

Gene ID: 10475, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TRIM38provided by HGNC
Official Full Name
tripartite motif containing 38provided by HGNC
Primary source
HGNC:HGNC:10059
See related
Ensembl:ENSG00000112343 AllianceGenome:HGNC:10059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF15; RORET
Summary
This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6p22.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (25962802..25991231)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25828703..25857166)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25963030..25991459)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B histone pseudogene 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:25898344-25898933 Neighboring gene solute carrier family 17 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24170 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:25971247-25972446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24171 Neighboring gene long intergenic non-protein coding RNA 2980 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:25999111-25999745 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:25999746-26000381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26016208-26017207 Neighboring gene H3 histone pseudogene 26

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy. Luo H, et al. Virology, 2023 Feb. PMID 36623352
  2. Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase. Liu X, et al. Virol J, 2011 Feb 10. PMID 21306652, Free PMC Article
  3. TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer. Wang X, et al. J Transl Med, 2021 Dec 14. PMID 34906161, Free PMC Article
  4. [Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]. Liu XL, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 2011 Feb. PMID 21789858
  5. TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation. Xue Q, et al. PLoS One, 2012. PMID 23056470, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.
    Title: Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.
  2. Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
    Title: Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.
  3. The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-alpha antiviral therapy.
    Title: The antiviral activity of tripartite motif protein 38 in hepatitis B virus replication and gene expression and its association with treatment responses during PEG-IFN-α antiviral therapy.
  4. TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer.
    Title: TRIM38 triggers the uniquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer.
  5. Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38)
    Title: NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes.
  6. TRIM38 may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TRIF for degradation
    Title: TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.
  7. NF-kappaB is activated in response to TRIM38.
    Title: [Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways].
  8. Enterovirus 71 infection induces degradation of TRIM38.
    Title: Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC8946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase TRIM38
Names
RING-type E3 ubiquitin transferase TRIM38
Ro/SSA ribonucleoprotein homolog
ring finger protein 15
tripartite motif-containing protein 38
zinc finger protein RoRet
NP_006346.1
XP_047274036.1
XP_054210007.1
XP_054210008.1
XP_054210009.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006355.5 → NP_006346.1  E3 ubiquitin-protein ligase TRIM38

    See identical proteins and their annotated locations for NP_006346.1

    Status: REVIEWED

    Source sequence(s)
    AK313248, KC877159, U91328
    Consensus CDS
    CCDS4568.1
    UniProtKB/Swiss-Prot
    B2R862, O00635
    Related
    ENSP00000349596.2, ENST00000357085.5
    Conserved Domains (3) summary
    smart00336
    Location:88 → 129
    BBOX; B-Box-type zinc finger
    cd15815
    Location:280 → 461
    SPRY_PRY_TRIM38; PRY/SPRY domain of tripartite motif-binding protein 38 (TRIM38), also known as Ring finger protein 15 (RNF15)
    cd16600
    Location:13 → 63
    RING-HC_TRIM38_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 38 (TRIM38) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    25962802..25991231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418080.1 → XP_047274036.1  E3 ubiquitin-protein ligase TRIM38 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    25828703..25857166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354032.1 → XP_054210007.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

    UniProtKB/Swiss-Prot
    B2R862, O00635

  2. XM_054354034.1 → XP_054210009.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

    UniProtKB/Swiss-Prot
    B2R862, O00635

  3. XM_054354033.1 → XP_054210008.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

    UniProtKB/Swiss-Prot
    B2R862, O00635

RNA

  1. XR_008487235.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00635.1 GenPept UniProtKB/Swiss-Prot:O00635

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous