Arrdc3 arrestin domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arrdc3provided by MGI
Official Full Name: arrestin domain containing 3provided by MGI
Primary source: MGI:MGI:2145242
See related: Ensembl:ENSMUSG00000074794 AllianceGenome:MGI:2145242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1376
Summary: Predicted to enable beta-3 adrenergic receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Is expressed in central nervous system; liver; lung; olfactory epithelium; and retina nuclear layer. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 18.7), limb E14.5 (RPKM 10.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C2; 13 41.95 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (81031508..81044161)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (80883384..80896042)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
Title: Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1.
Title: Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1.
Comprehensive multi-omics analysis uncovers a group of TGF-beta-regulated genes among lncRNA EPR direct transcriptional targets.
Title: Comprehensive multi-omics analysis uncovers a group of TGF-β-regulated genes among lncRNA EPR direct transcriptional targets.
Arrdc2 and Arrdc3 are a novel set of genes that may be implicated in the regulation of skeletal muscle mass.
Title: Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli.
data reveal a role for Arrdc3 in the regulation of Ucp1 expression in adipocytes. However, this adipocyte effect is insufficient to generate the obesity-resistant phenotype of mice with ubiquitous deletion of Arrdc3, indicating a likely role for Arrdc3 in cells other than adipocytes
Title: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.
In the course of breeding our own Arrdc3-deficient mice, we observed two novel phenotypes in homozygotes: skin abnormalities, and embryonic lethality on normal chow diet, but not on high fat diet.
Title: Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.
The obesity risk locus contains a single gene, arrestin domain-containing 3 (ARRDC3), which interacts directly with beta-adrenergic receptors and is gender-specific.
Title: The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins
Title: Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237065

AI450344 (e-PCR)
- UniSTS:160322

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-3 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of heat generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of heat generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arrestin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042591.2 → NP_001036056.1 arrestin domain-containing protein 3

See identical proteins and their annotated locations for NP_001036056.1

Status: VALIDATED

Source sequence(s)

CT009711

Consensus CDS

CCDS36736.1

UniProtKB/Swiss-Prot

Q4KMN0, Q7TPQ9, Q80TE6, Q8K0L7

UniProtKB/TrEMBL

Q0GJK3

Related

ENSMUSP00000096957.3, ENSMUST00000099356.10

Conserved Domains (2) summary

smart01017
Location:187 → 314

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:22 → 165

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

NR_153410.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009711

Related

ENSMUST00000159690.8
NR_153411.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT009711

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

81031508..81044161

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247082.1 → XP_030102942.1 arrestin domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

E0CZE1

Conserved Domains (1) summary

smart01017
Location:5 → 94

Arrestin_C; Arrestin (or S-antigen), C-terminal domain
XM_030247081.1 → XP_030102941.1 arrestin domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

E0CZE1

Related

ENSMUSP00000125455.2, ENSMUST00000161441.2

Conserved Domains (1) summary

smart01017
Location:5 → 94

Arrestin_C; Arrestin (or S-antigen), C-terminal domain
XM_006517017.4 → XP_006517080.1 arrestin domain-containing protein 3 isoform X1

Conserved Domains (2) summary

smart01017
Location:96 → 223

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:13 → 74

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178917.2: Suppressed sequence

Description

NM_178917.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.