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LINC01977 long intergenic non-protein coding RNA 1977 [ Homo sapiens (human) ]

Gene ID: 105371919, updated on 10-Oct-2023

Summary

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Official Symbol
LINC01977provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1977provided by HGNC
Primary source
HGNC:HGNC:52804
See related
AllianceGenome:HGNC:52804
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
17q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (79823452..79827704)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (80721272..80725514)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77797251..77801503)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77767145-77767859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77768921-77769661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9085 Neighboring gene Sharpr-MPRA regulatory region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9088 Neighboring gene chromobox 8 Neighboring gene uncharacterized LOC124904071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77784936-77785461 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:77800185-77800461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77800651-77801152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77801153-77801652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77805673-77806494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77809787-77810608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9092 Neighboring gene Sharpr-MPRA regulatory region 202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77811431-77812254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77812255-77813076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77814721-77815544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77815545-77816366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9095 Neighboring gene chromobox 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:77824032-77825231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12924 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:77842993-77843520 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:77843521-77844050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77862335-77862836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77875585-77876566 Neighboring gene long intergenic non-protein coding RNA 1979 Neighboring gene long intergenic non-protein coding RNA 1978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway. Zhang T, et al. J Hematol Oncol, 2022 Aug 18. PMID 35982471, Free PMC Article
  2. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-beta/SMAD3 pathway.
    Title: Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_146504.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC100791, BM714401, BM781621

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    79823452..79827704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    80721272..80725514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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