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HTATIP2 HIV-1 Tat interactive protein 2 [ Homo sapiens (human) ]

Gene ID: 10553, updated on 2-Nov-2024

Summary

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Official Symbol
HTATIP2provided by HGNC
Official Full Name
HIV-1 Tat interactive protein 2provided by HGNC
Primary source
HGNC:HGNC:16637
See related
Ensembl:ENSG00000109854 MIM:605628; AllianceGenome:HGNC:16637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CC3; TIP30; SDR44U1
Summary
Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum (RPKM 33.4), small intestine (RPKM 30.9) and 24 other tissues See more
Orthologs
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Genomic context

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See HTATIP2 in Genome Data Viewer
Location:
11p15.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (20363714..20383782)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (20484405..20504464)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (20385260..20405328)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:20177816-20179015 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20182401-20182902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20182903-20183402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:20184527-20185028 Neighboring gene uncharacterized LOC105376583 Neighboring gene developing brain homeobox 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:20234917-20235147 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19843 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20364173-20364700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4525 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:20385467-20385609 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:20388793-20389992 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20406589-20407090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20409013-20409620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:20409621-20410227 Neighboring gene protein arginine methyltransferase 3 Neighboring gene uncharacterized LOC124902808 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19926 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3204 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:20566010-20566716 Neighboring gene uncharacterized LOC105376584 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_20020

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer. Park SY, et al. Technol Cancer Res Treat, 2024 Jan-Dec. PMID 38303513, Free PMC Article
  2. Tat-Interacting Protein 30 (TIP30) Expression Serves as a New Biomarker for Tumor Prognosis: A Systematic Review and Meta-Analysis. Xu T, et al. PLoS One, 2016. PMID 28036326, Free PMC Article
  3. Association of TIP30 expression and prognosis of hepatocellular carcinoma in patients with HBV infection. Zhang X, et al. Cancer Med, 2016 Sep. PMID 27418384, Free PMC Article
  4. Overexpression of TIP30 inhibits the growth and invasion of glioma cells. Hu Y, et al. Mol Med Rep, 2016 Jan. PMID 26718891, Free PMC Article
  5. Nonsynonymous single nucleotide polymorphisms in the complement component 3 gene are associated with risk of age-related macular degeneration: a meta-analysis. Qian-Qian Y, et al. Gene, 2015 May 1. PMID 25688879

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer.
    Title: HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer.
  2. HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia.
    Title: HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia.
  3. Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.
    Title: Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.
  4. The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis
    Title: The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis.
  5. TIP30 overcomes gefitinib resistance by regulating cytoplasmic and nuclear EGFR signaling in non-small-cell lung cancer.
    Title: TIP30 overcomes gefitinib resistance by regulating cytoplasmic and nuclear EGFR signaling in non-small-cell lung cancer.
  6. Clinical significance of changes in AFP, HTATIP2/TIP30, B7-H4 and inflammatory cytokines after transcatheter arterial chemoembolization.
    Title: Clinical significance of changes in AFP, HTATIP2/TIP30, B7-H4 and inflammatory cytokines after transcatheter arterial chemoembolization.
  7. Here, we identified the tumor suppressor protein TIP30 as novel inhibitor of cardiac hypertrophy and dysfunction. The results are relevant for human disease, since the authors found diminished cardiac TIP30 levels in samples from patients suffering from end-stage heart failure or hypertrophic cardiomyopathy.
    Title: TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.
  8. Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels were significantly different in the hepatocellular carcinoma patients compared to controls, and those with chronic hepatitis and liver cirrhosis (p<0.01 each).
    Title: Combined detection of AFP-L3, GP73 and TIP30 enhances diagnostic accuracy for HBV-related cirrhosis and hepatocellular carcinoma.
  9. These results suggest that TIP30, as a tumor suppressor in the bladder cancer, might be served as a target in cancer therapies in the future.
    Title: Overexpression of Tat-interacting protein 30 inhibits the proliferation, migration, invasion and promotes apoptosis in bladder cancer cells.
  10. Binding of HIV1 Tat to TIP30 enhanced epithelial-to-mesenchymal transition and metastasis by regulating the nuclear translocation of Snail.
    Title: Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with HTATIP2 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat stimulates the phosphorylation of the RNA polymerase II C-terminal domain by TIP30 PubMed
tat TIP30 interacts with amino acids 1-48 of HIV-1 Tat, including the Tat activation domain, and enhances Tat activation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in mitochondrion HTP PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
oxidoreductase HTATIP2
Names
30 kDa HIV-1 TAT-interacting protein
HIV-1 TAT-interactive protein 2
HIV-1 Tat interactive protein 2, 30kDa
Tat-interacting protein (30kD)
short chain dehydrogenase/reductase family 44U, member 1
NP_001091990.1
NP_001091991.1
NP_001091992.1
NP_001091993.1
NP_006401.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098520.2 → NP_001091990.1  oxidoreductase HTATIP2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC025972, AK222969, BC015358, BP382529
    Consensus CDS
    CCDS44553.1
    UniProtKB/Swiss-Prot
    Q9BUP3
    Related
    ENSP00000392985.2, ENST00000419348.6
    Conserved Domains (2) summary
    cd05250
    Location:53 → 265
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    COG0702
    Location:55 → 205
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

  2. NM_001098521.2 → NP_001091991.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001091991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC025972, AK222969, BC015358, DB450790
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000387876.2, ENST00000443524.6
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  3. NM_001098522.2 → NP_001091992.1  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_001091992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' end and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC025972, AI193677, AK222969, BC015358
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000394259.2, ENST00000451739.7
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

  4. NM_001098523.2 → NP_001091993.1  oxidoreductase HTATIP2 isoform c

    See identical proteins and their annotated locations for NP_001091993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and coding region, compared to variant 1. The resulting isoform (c, also known as TC3) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC025972, AF092095, AW963626
    Consensus CDS
    CCDS53613.1
    UniProtKB/Swiss-Prot
    Q9BUP3
    Related
    ENSP00000432107.1, ENST00000532081.1
    Conserved Domains (1) summary
    cl21454
    Location:19 → 101
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_006410.5 → NP_006401.3  oxidoreductase HTATIP2 isoform b

    See identical proteins and their annotated locations for NP_006401.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b, also known as CC3) with a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AK222969, BC015358, BF681178
    Consensus CDS
    CCDS7852.1
    UniProtKB/Swiss-Prot
    A8K7S7, D3DQY8, O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3, Q9BUP3
    UniProtKB/TrEMBL
    E9PI87
    Related
    ENSP00000397752.2, ENST00000421577.6
    Conserved Domains (1) summary
    cd05250
    Location:19 → 231
    CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    20363714..20383782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    20484405..20504464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUP3.2 GenPept UniProtKB/Swiss-Prot:Q9BUP3

Gene LinkOut

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Chemical Information
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