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SIVA1 SIVA1 apoptosis inducing factor [ Homo sapiens (human) ]

Gene ID: 10572, updated on 2-Nov-2024

Summary

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Official Symbol
SIVA1provided by HGNC
Official Full Name
SIVA1 apoptosis inducing factorprovided by HGNC
Primary source
HGNC:HGNC:17712
See related
Ensembl:ENSG00000184990 MIM:605567; AllianceGenome:HGNC:17712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIVA; CD27BP; Siva-1; Siva-2
Summary
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

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See SIVA1 in Genome Data Viewer
Location:
14q32.33
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104753147..104759654)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (98996033..99002540)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105219484..105225991)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene uncharacterized LOC124903396 Neighboring gene uncharacterized LOC107984670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105209535-105210340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105212701-105213200 Neighboring gene uncharacterized LOC107987209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6196 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:105219303-105219804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105225732-105226680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105226681-105227627 Neighboring gene uncharacterized LOC102723342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105233884-105234434 Neighboring gene Sharpr-MPRA regulatory region 15301 Neighboring gene AKT serine/threonine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105257987-105258628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105259269-105259910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105259911-105260550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105260551-105261192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6197 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105263234-105264006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105264007-105264779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105270463-105270962 Neighboring gene zinc finger and BTB domain containing 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo. Vermehren-Schmaedick A, et al. PLoS One, 2024. PMID 38722955, Free PMC Article
  2. Requirement for Siva-1 for replication of influenza A virus through apoptosis induction. Shiozaki T, et al. J Gen Virol, 2011 Feb. PMID 21048035
  3. Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway. Kong FB, et al. Mol Med Rep, 2020 Aug. PMID 32626967, Free PMC Article
  4. The role of the pro-apoptotic protein Siva in the pathogenesis of Familial Mediterranean fever: A structural and functional analysis. Goulielmos GN, et al. Biochem Biophys Res Commun, 2010 Nov 5. PMID 20934406
  5. PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1. Xu F, et al. Eur Rev Med Pharmacol Sci, 2020 Apr. PMID 32329870

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
    Title: Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
  2. Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.
    Title: Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.
  3. N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.
    Title: N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.
  4. Siva1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NFkappaB pathway.
    Title: Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway.
  5. PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.
    Title: PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.
  6. SIVA1 enhances SSBP3 ubiquitination and promotes SSBP3 protein turnover
    Title: [SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms].
  7. Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
    Title: Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2.
  8. These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
    Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
  9. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
    Title: Preliminary research on the expression, purification and function of the apoptotic fusion protein, Sival.
  10. electrical stimulation -inducible SIVA1 modulates p53 activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
    Title: Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of SIVA1, apoptosis-inducing factor (SIVA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Envelope transmembrane glycoprotein gp41 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CD27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CD27 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables virus receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apoptosis regulatory protein Siva
Names
CD27-binding (Siva) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029449.1 RefSeqGene

    Range
    5015..11522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006427.4 → NP_006418.2  apoptosis regulatory protein Siva isoform 1

    See identical proteins and their annotated locations for NP_006418.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant and longer transcript. It encodes isoform 1 and includes the apoptotic properties of Siva.
    Source sequence(s)
    BC034562, BU195069, CK001877
    Consensus CDS
    CCDS9992.1
    UniProtKB/Swiss-Prot
    O15304, Q96P98, Q9UPD6
    UniProtKB/TrEMBL
    Q53FF7
    Related
    ENSP00000329213.6, ENST00000329967.11
    Conserved Domains (1) summary
    pfam05458
    Location:1 → 175
    Siva; Cd27 binding protein (Siva)

  2. NM_021709.3 → NP_068355.1  apoptosis regulatory protein Siva isoform 2

    See identical proteins and their annotated locations for NP_068355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC034562, BU195069
    Consensus CDS
    CCDS9993.1
    UniProtKB/Swiss-Prot
    O15304
    Related
    ENSP00000329447.6, ENST00000347067.9
    Conserved Domains (1) summary
    pfam05458
    Location:1 → 110
    Siva; Cd27 binding protein (Siva)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    104753147..104759654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536360.3 → XP_011534662.1  apoptosis regulatory protein Siva isoform X1

    See identical proteins and their annotated locations for XP_011534662.1

    UniProtKB/TrEMBL
    B4DTY2
    Related
    ENSP00000485991.1, ENST00000535554.4
    Conserved Domains (1) summary
    pfam05458
    Location:1 → 157
    Siva; Cd27 binding protein (Siva)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    98996033..99002540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375275.1 → XP_054231250.1  apoptosis regulatory protein Siva isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15304.2 GenPept UniProtKB/Swiss-Prot:O15304

Gene LinkOut

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