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TACC2 transforming acidic coiled-coil containing protein 2 [ Homo sapiens (human) ]

Gene ID: 10579, updated on 3-Apr-2024

Summary

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Official Symbol
TACC2provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 2provided by HGNC
Primary source
HGNC:HGNC:11523
See related
Ensembl:ENSG00000138162 MIM:605302; AllianceGenome:HGNC:11523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZU-1; ECTACC
Summary
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues See more
Orthologs
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Genomic context

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Location:
10q26.13
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (121989163..122254542)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (122885504..123150842)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123748678..124014057)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arginyltransferase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123687446-123688312 Neighboring gene Sharpr-MPRA regulatory region 2750 Neighboring gene ATE1 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:123734371-123735166 Neighboring gene uncharacterized LOC124902517 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:123778189-123779388 Neighboring gene Sharpr-MPRA regulatory region 10515 Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354 Neighboring gene MPRA-validated peak1120 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123836619-123837120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123844981-123845482 Neighboring gene Sharpr-MPRA regulatory regions 1076 and 11287 Neighboring gene uncharacterized LOC124902518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123914119-123915090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123931653-123932226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123933375-123933946 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123938237-123938774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123939851-123940388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123952053-123952808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123955355-123956017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123959504-123960449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123960450-123961394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123992934-123993434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124005137-124006083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124027705-124028206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124050601-124051101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124053014-124054004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4142 Neighboring gene BTB domain containing 16 Neighboring gene RNA, U6 small nuclear 728, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter. Ito Y, et al. Sci Rep, 2021 Apr 30. PMID 33931666, Free PMC Article
  2. High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis. Shakya M, et al. Cancer Biomark, 2018. PMID 29843208, Free PMC Article
  3. TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation. Onodera Y, et al. Cancer Med, 2016 Aug. PMID 27333920, Free PMC Article
  4. Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance. Cheng S, et al. Cancer Genomics Proteomics, 2010 Mar-Apr. PMID 20335520
  5. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. Pu JJ, et al. Cytokine, 2001 Feb 7. PMID 11161455

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
    Title: Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
  2. Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
    Title: Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
  3. TACC2 protein is expressed mainly in the nucleus of the endometrial cancer cells.
    Title: Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.
  4. This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma.
    Title: High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis.
  5. These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.
    Title: TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation.
  6. Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
    Title: Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
  7. Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer.
    Title: TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.
  8. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
    Title: Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
  9. TACC2 may mediate an oncogenic effect on breast cancer cells.
    Title: Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 2
Names
anti zuai-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029948.3 RefSeqGene

    Range
    5002..270381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291876.2 → NP_001278805.2  transforming acidic coiled-coil-containing protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several internal exons in the CDS compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS76348.1
    UniProtKB/TrEMBL
    B2RWP4, E7EMZ9
    Related
    ENSP00000427618.1, ENST00000515603.5
    Conserved Domains (2) summary
    PHA03247
    Location:15 → 468
    PHA03247; large tegument protein UL36; Provisional
    pfam05010
    Location:2620 → 2820
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  2. NM_001291877.2 → NP_001278806.2  transforming acidic coiled-coil-containing protein 2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks several internal exons and uses an alternate splice site in the CDS compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS76349.1
    UniProtKB/TrEMBL
    B7ZMJ9, E9PBC6
    Related
    ENSP00000424467.1, ENST00000515273.5
    Conserved Domains (2) summary
    PHA03247
    Location:15 → 468
    PHA03247; large tegument protein UL36; Provisional
    pfam05010
    Location:2669 → 2869
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  3. NM_001291878.2 → NP_001278807.1  transforming acidic coiled-coil-containing protein 2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate structure in the 5' UTR and 5' coding region and lacks an internal exon compared to variant 1. The encoded isoform (g) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL135793, BC039311, BC141837, R46074
    Consensus CDS
    CCDS76351.1
    UniProtKB/TrEMBL
    D6RAA5
    Related
    ENSP00000422815.1, ENST00000369004.7
    Conserved Domains (3) summary
    pfam05010
    Location:802 → 1002
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:921 → 1001
    FadA; Adhesion protein FadA
    cl23765
    Location:821 → 923
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. NM_001291879.2 → NP_001278808.1  transforming acidic coiled-coil-containing protein 2 isoform h

    See identical proteins and their annotated locations for NP_001278808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region and lacks two internal coding exons compared to variant 1. These differences result in the use of a downstream AUG compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC063960, AL135793, BC015736, R46074
    Consensus CDS
    CCDS76352.1
    UniProtKB/TrEMBL
    Q4VXL4
    Related
    ENSP00000357997.1, ENST00000369001.5
    Conserved Domains (1) summary
    pfam05010
    Location:369 → 569
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  5. NM_006997.4 → NP_008928.1  transforming acidic coiled-coil-containing protein 2 isoform d

    See identical proteins and their annotated locations for NP_008928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a different structure for its 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF095791, AL135793, BC039311, R46074
    Consensus CDS
    CCDS7627.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000260733.3, ENST00000260733.7
    Conserved Domains (2) summary
    pfam05010
    Location:820 → 1020
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:939 → 1019
    FadA; Adhesion protein FadA

  6. NM_206860.3 → NP_996742.1  transforming acidic coiled-coil-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_996742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different structure for its 5' UTR and 5' coding region, and also lacks an internal coding exon compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL135793, BC039311, R46074
    Consensus CDS
    CCDS7628.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000353763.3, ENST00000360561.7
    Conserved Domains (3) summary
    pfam05010
    Location:790 → 990
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:909 → 989
    FadA; Adhesion protein FadA
    cl11495
    Location:785 → 917
    IncFII_repA; IncFII RepA protein family

  7. NM_206861.3 → NP_996743.1  transforming acidic coiled-coil-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_996743.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three internal in-frame exons compared to variant 1. The resulting protein (isoform b) is shorter compared to isoform a. Isoform b has also been called the 'short' isoform
    Source sequence(s)
    AF528098, AL135793, AL731566, R46074
    Consensus CDS
    CCDS7625.1
    UniProtKB/Swiss-Prot
    O95359
    Related
    ENSP00000425062.1, ENST00000513429.5
    Conserved Domains (2) summary
    pfam05010
    Location:888 → 1088
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:1007 → 1087
    FadA; Adhesion protein FadA

  8. NM_206862.4 → NP_996744.4  transforming acidic coiled-coil-containing protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Isoform a has also been called the 'long' isoform.
    Source sequence(s)
    AC063960, AL135793, AL731566
    Consensus CDS
    CCDS7626.1
    UniProtKB/Swiss-Prot
    O95359, Q4VXL0, Q4VXL3, Q4VXL6, Q4VXL7, Q5U5T7, Q86WG6, Q86WG7, Q8TCK9, Q9BVQ1, Q9NZ41, Q9NZR5
    UniProtKB/TrEMBL
    B2RWP4
    Related
    ENSP00000358001.1, ENST00000369005.6
    Conserved Domains (2) summary
    pfam05010
    Location:2742 → 2942
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl26464
    Location:15 → 468
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    121989163..122254542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424457.1 → XP_047280413.1  transforming acidic coiled-coil-containing protein 2 isoform X28

  2. XM_047424465.1 → XP_047280421.1  transforming acidic coiled-coil-containing protein 2 isoform X37

  3. XM_024447756.1 → XP_024303524.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2805 → 3005
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2185 → 2572
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24 → 488
    Atrophin-1; Atrophin-1 family

  4. XM_005269390.1 → XP_005269447.1  transforming acidic coiled-coil-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2774 → 2974
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2893 → 2973
    FadA; Adhesion protein FadA
    pfam13863
    Location:2778 → 2879
    DUF4200; Domain of unknown function (DUF4200)

  5. XM_017015485.1 → XP_016870974.1  transforming acidic coiled-coil-containing protein 2 isoform X13

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    PTZ00449
    Location:2185 → 2550
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:24 → 488
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:2756 → 2947
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006717552.1 → XP_006717615.1  transforming acidic coiled-coil-containing protein 2 isoform X21

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2697 → 2897
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2816 → 2896
    FadA; Adhesion protein FadA
    cl02488
    Location:2736 → 2899
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_005269388.1 → XP_005269445.1  transforming acidic coiled-coil-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005269445.1

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2793 → 2993
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2912 → 2992
    FadA; Adhesion protein FadA
    pfam13863
    Location:2797 → 2898
    DUF4200; Domain of unknown function (DUF4200)

  8. XM_005269392.1 → XP_005269449.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2763 → 2963
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2882 → 2962
    FadA; Adhesion protein FadA
    cl02488
    Location:2802 → 2965
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_005269396.1 → XP_005269453.1  transforming acidic coiled-coil-containing protein 2 isoform X20

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2716 → 2916
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2835 → 2915
    FadA; Adhesion protein FadA
    cl02488
    Location:2755 → 2918
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_005269393.1 → XP_005269450.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2762 → 2962
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2881 → 2961
    FadA; Adhesion protein FadA
    pfam13863
    Location:2766 → 2867
    DUF4200; Domain of unknown function (DUF4200)

  11. XM_017015486.1 → XP_016870975.1  transforming acidic coiled-coil-containing protein 2 isoform X16

    UniProtKB/TrEMBL
    B2RWP4

  12. XM_006717553.1 → XP_006717616.1  transforming acidic coiled-coil-containing protein 2 isoform X24

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2685 → 2885
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2804 → 2884
    FadA; Adhesion protein FadA
    cl02488
    Location:2724 → 2887
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_017015484.1 → XP_016870973.1  transforming acidic coiled-coil-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    B2RWP4

  14. XM_006717548.1 → XP_006717611.1  transforming acidic coiled-coil-containing protein 2 isoform X11

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2758 → 2958
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2877 → 2957
    FadA; Adhesion protein FadA
    pfam13863
    Location:2762 → 2863
    DUF4200; Domain of unknown function (DUF4200)

  15. XM_017015487.1 → XP_016870976.1  transforming acidic coiled-coil-containing protein 2 isoform X17

    UniProtKB/TrEMBL
    B2RWP4

  16. XM_006717554.1 → XP_006717617.1  transforming acidic coiled-coil-containing protein 2 isoform X25

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2681 → 2881
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2800 → 2880
    FadA; Adhesion protein FadA
    cl02488
    Location:2720 → 2883
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  17. XM_024447761.1 → XP_024303529.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2760 → 2960
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2140 → 2527
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24 → 488
    Atrophin-1; Atrophin-1 family

  18. XM_047424449.1 → XP_047280405.1  transforming acidic coiled-coil-containing protein 2 isoform X12

  19. XM_047424453.1 → XP_047280409.1  transforming acidic coiled-coil-containing protein 2 isoform X19

  20. XM_047424455.1 → XP_047280411.1  transforming acidic coiled-coil-containing protein 2 isoform X23

  21. XM_005269399.1 → XP_005269456.1  transforming acidic coiled-coil-containing protein 2 isoform X31

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2640 → 2840
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:2759 → 2839
    FadA; Adhesion protein FadA
    pfam13863
    Location:2644 → 2745
    DUF4200; Domain of unknown function (DUF4200)

  22. XM_024447760.1 → XP_024303528.1  transforming acidic coiled-coil-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (4) summary
    pfam05010
    Location:2763 → 2963
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2143 → 2530
    DUF4045; Domain of unknown function (DUF4045)
    cl26386
    Location:1526 → 1987
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:24 → 488
    Atrophin-1; Atrophin-1 family

  23. XM_047424458.1 → XP_047280414.1  transforming acidic coiled-coil-containing protein 2 isoform X30

  24. XM_024447762.1 → XP_024303530.1  transforming acidic coiled-coil-containing protein 2 isoform X18

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2718 → 2918
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2098 → 2485
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24 → 488
    Atrophin-1; Atrophin-1 family

  25. XM_047424461.1 → XP_047280417.1  transforming acidic coiled-coil-containing protein 2 isoform X34

  26. XM_017015489.1 → XP_016870978.1  transforming acidic coiled-coil-containing protein 2 isoform X29

    UniProtKB/TrEMBL
    B2RWP4

  27. XM_047424462.1 → XP_047280418.1  transforming acidic coiled-coil-containing protein 2 isoform X35

  28. XM_017015488.1 → XP_016870977.1  transforming acidic coiled-coil-containing protein 2 isoform X26

    UniProtKB/TrEMBL
    B2RWP4

  29. XM_047424463.1 → XP_047280419.1  transforming acidic coiled-coil-containing protein 2 isoform X36

  30. XM_024447763.1 → XP_024303531.1  transforming acidic coiled-coil-containing protein 2 isoform X38

    Conserved Domains (3) summary
    pfam05010
    Location:996 → 1196
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:376 → 763
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24 → 222
    Atrophin-1; Atrophin-1 family

  31. XM_024447764.1 → XP_024303532.1  transforming acidic coiled-coil-containing protein 2 isoform X39

    Conserved Domains (2) summary
    pfam05010
    Location:951 → 1151
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:331 → 718
    DUF4045; Domain of unknown function (DUF4045)

  32. XM_011539130.1 → XP_011537432.1  transforming acidic coiled-coil-containing protein 2 isoform X40

    Conserved Domains (3) summary
    pfam05010
    Location:908 → 1108
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:1027 → 1107
    FadA; Adhesion protein FadA
    cl23765
    Location:927 → 1029
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  33. XM_024447758.1 → XP_024303526.1  transforming acidic coiled-coil-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2804 → 3004
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2184 → 2571
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:23 → 487
    Atrophin-1; Atrophin-1 family

  34. XM_024447759.1 → XP_024303527.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2785 → 2985
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2165 → 2552
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:15 → 468
    Atrophin-1; Atrophin-1 family

  35. XM_047424451.1 → XP_047280407.1  transforming acidic coiled-coil-containing protein 2 isoform X15

  36. XM_024447757.2 → XP_024303525.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RWP4
    Conserved Domains (3) summary
    pfam05010
    Location:2805 → 3005
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:2185 → 2572
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:24 → 488
    Atrophin-1; Atrophin-1 family

  37. XM_047424448.1 → XP_047280404.1  transforming acidic coiled-coil-containing protein 2 isoform X5

  38. XM_047424456.1 → XP_047280412.1  transforming acidic coiled-coil-containing protein 2 isoform X27

  39. XM_047424452.1 → XP_047280408.1  transforming acidic coiled-coil-containing protein 2 isoform X15

  40. XM_047424454.1 → XP_047280410.1  transforming acidic coiled-coil-containing protein 2 isoform X22

  41. XM_047424460.1 → XP_047280416.1  transforming acidic coiled-coil-containing protein 2 isoform X33

    UniProtKB/TrEMBL
    E7EMZ9

  42. XM_047424450.1 → XP_047280406.1  transforming acidic coiled-coil-containing protein 2 isoform X14

  43. XM_047424459.1 → XP_047280415.1  transforming acidic coiled-coil-containing protein 2 isoform X32

  44. XM_047424464.1 → XP_047280420.1  transforming acidic coiled-coil-containing protein 2 isoform X37

  45. XM_047424466.1 → XP_047280422.1  transforming acidic coiled-coil-containing protein 2 isoform X43

  46. XM_024447765.2 → XP_024303533.1  transforming acidic coiled-coil-containing protein 2 isoform X41

    Conserved Domains (2) summary
    pfam05010
    Location:863 → 1063
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl25751
    Location:243 → 630
    DUF4045; Domain of unknown function (DUF4045)

  47. XM_011539132.3 → XP_011537434.1  transforming acidic coiled-coil-containing protein 2 isoform X42

    UniProtKB/TrEMBL
    Q4VXL8
    Related
    ENSP00000357995.1, ENST00000368999.5
    Conserved Domains (3) summary
    pfam05010
    Location:832 → 1032
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:951 → 1031
    FadA; Adhesion protein FadA
    cl23765
    Location:851 → 953
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    122885504..123150842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364531.1 → XP_054220506.1  transforming acidic coiled-coil-containing protein 2 isoform X28

  2. XM_054364541.1 → XP_054220516.1  transforming acidic coiled-coil-containing protein 2 isoform X37

  3. XM_054364510.1 → XP_054220485.1  transforming acidic coiled-coil-containing protein 2 isoform X8

  4. XM_054364501.1 → XP_054220476.1  transforming acidic coiled-coil-containing protein 2 isoform X1

  5. XM_054364505.1 → XP_054220480.1  transforming acidic coiled-coil-containing protein 2 isoform X4

  6. XM_054364521.1 → XP_054220496.1  transforming acidic coiled-coil-containing protein 2 isoform X18

  7. XM_054364503.1 → XP_054220478.1  transforming acidic coiled-coil-containing protein 2 isoform X2

  8. XM_054364512.1 → XP_054220487.1  transforming acidic coiled-coil-containing protein 2 isoform X10

  9. XM_054364507.1 → XP_054220482.1  transforming acidic coiled-coil-containing protein 2 isoform X5

  10. XM_054364517.1 → XP_054220492.1  transforming acidic coiled-coil-containing protein 2 isoform X15

  11. XM_054364508.1 → XP_054220483.1  transforming acidic coiled-coil-containing protein 2 isoform X6

  12. XM_054364515.1 → XP_054220490.1  transforming acidic coiled-coil-containing protein 2 isoform X13

  13. XM_054364504.1 → XP_054220479.1  transforming acidic coiled-coil-containing protein 2 isoform X3

  14. XM_054364509.1 → XP_054220484.1  transforming acidic coiled-coil-containing protein 2 isoform X7

  15. XM_054364513.1 → XP_054220488.1  transforming acidic coiled-coil-containing protein 2 isoform X11

  16. XM_054364520.1 → XP_054220495.1  transforming acidic coiled-coil-containing protein 2 isoform X17

  17. XM_054364514.1 → XP_054220489.1  transforming acidic coiled-coil-containing protein 2 isoform X12

  18. XM_054364529.1 → XP_054220504.1  transforming acidic coiled-coil-containing protein 2 isoform X26

  19. XM_054364524.1 → XP_054220499.1  transforming acidic coiled-coil-containing protein 2 isoform X21

  20. XM_054364523.1 → XP_054220498.1  transforming acidic coiled-coil-containing protein 2 isoform X20

  21. XM_054364511.1 → XP_054220486.1  transforming acidic coiled-coil-containing protein 2 isoform X9

  22. XM_054364519.1 → XP_054220494.1  transforming acidic coiled-coil-containing protein 2 isoform X16

  23. XM_054364528.1 → XP_054220503.1  transforming acidic coiled-coil-containing protein 2 isoform X25

  24. XM_054364537.1 → XP_054220512.1  transforming acidic coiled-coil-containing protein 2 isoform X34

  25. XM_054364539.1 → XP_054220514.1  transforming acidic coiled-coil-containing protein 2 isoform X36

  26. XM_054364522.1 → XP_054220497.1  transforming acidic coiled-coil-containing protein 2 isoform X19

  27. XM_054364526.1 → XP_054220501.1  transforming acidic coiled-coil-containing protein 2 isoform X23

  28. XM_054364532.1 → XP_054220507.1  transforming acidic coiled-coil-containing protein 2 isoform X29

  29. XM_054364533.1 → XP_054220508.1  transforming acidic coiled-coil-containing protein 2 isoform X30

  30. XM_054364527.1 → XP_054220502.1  transforming acidic coiled-coil-containing protein 2 isoform X24

  31. XM_054364534.1 → XP_054220509.1  transforming acidic coiled-coil-containing protein 2 isoform X31

  32. XM_054364538.1 → XP_054220513.1  transforming acidic coiled-coil-containing protein 2 isoform X35

  33. XM_054364542.1 → XP_054220517.1  transforming acidic coiled-coil-containing protein 2 isoform X38

  34. XM_054364543.1 → XP_054220518.1  transforming acidic coiled-coil-containing protein 2 isoform X39

  35. XM_054364544.1 → XP_054220519.1  transforming acidic coiled-coil-containing protein 2 isoform X40

  36. XM_054364502.1 → XP_054220477.1  transforming acidic coiled-coil-containing protein 2 isoform X1

  37. XM_054364516.1 → XP_054220491.1  transforming acidic coiled-coil-containing protein 2 isoform X14

  38. XM_054364506.1 → XP_054220481.1  transforming acidic coiled-coil-containing protein 2 isoform X5

  39. XM_054364518.1 → XP_054220493.1  transforming acidic coiled-coil-containing protein 2 isoform X15

  40. XM_054364525.1 → XP_054220500.1  transforming acidic coiled-coil-containing protein 2 isoform X22

  41. XM_054364535.1 → XP_054220510.1  transforming acidic coiled-coil-containing protein 2 isoform X32

  42. XM_054364530.1 → XP_054220505.1  transforming acidic coiled-coil-containing protein 2 isoform X27

  43. XM_054364536.1 → XP_054220511.1  transforming acidic coiled-coil-containing protein 2 isoform X33

  44. XM_054364540.1 → XP_054220515.1  transforming acidic coiled-coil-containing protein 2 isoform X37

  45. XM_054364547.1 → XP_054220522.1  transforming acidic coiled-coil-containing protein 2 isoform X43

  46. XM_054364545.1 → XP_054220520.1  transforming acidic coiled-coil-containing protein 2 isoform X43

  47. XM_054364546.1 → XP_054220521.1  transforming acidic coiled-coil-containing protein 2 isoform X43

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95359.3 GenPept UniProtKB/Swiss-Prot:O95359

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