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POLR3F RNA polymerase III subunit F [ Homo sapiens (human) ]

Gene ID: 10621, updated on 11-Apr-2024

Summary

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Official Symbol
POLR3Fprovided by HGNC
Official Full Name
RNA polymerase III subunit Fprovided by HGNC
Primary source
HGNC:HGNC:15763
See related
Ensembl:ENSG00000132664 MIM:617455; AllianceGenome:HGNC:15763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C34; RPC6; RPC39; IMD101
Summary
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

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See POLR3F in Genome Data Viewer
Location:
20p11.23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18467390..18484646)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18518490..18535746)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18448034..18465290)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:18447554-18448172 Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18477654-18478218 Neighboring gene RB binding protein 9, serine hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence. Wang Y, et al. Biochim Biophys Acta, 2011 Jan. PMID 20888865, Free PMC Article
  2. Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters. Paulsen T, et al. Nucleic Acids Res, 2019 May 21. PMID 30828735, Free PMC Article
  3. PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. Zhou D, et al. J Mol Signal, 2007 Jul 5. PMID 17612402, Free PMC Article
  4. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones E, et al. Exp Cell Res, 2000 Jan 10. PMID 10623476
  5. Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Mertens C, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11416169, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 101 (varicella zoster virus-specific)
MedGen: C5676983 OMIM: 619872 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) III (DNA directed) polypeptide F (POLR3F) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed 5'-3' RNA polymerase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase III NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC6
Names
RNA polymerase III C39 subunit
RNA polymerase III subunit C6
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
polymerase (RNA) III subunit F
NP_001269455.1
NP_001397750.1
NP_006457.2
XP_047295792.1
XP_047295793.1
XP_054178826.1
XP_054178827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282526.2 → NP_001269455.1  DNA-directed RNA polymerase III subunit RPC6 isoform 2

    See identical proteins and their annotated locations for NP_001269455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL121893
    Consensus CDS
    CCDS93016.1
    UniProtKB/TrEMBL
    Q05DB8, Q53FI8
    Related
    ENSP00000513375.1, ENST00000462997.6
    Conserved Domains (1) summary
    pfam05158
    Location:1 → 274
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

  2. NM_001410821.1 → NP_001397750.1  DNA-directed RNA polymerase III subunit RPC6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL121893
    Consensus CDS
    CCDS93015.1
    UniProtKB/TrEMBL
    A0A8V8TMS0
    Related
    ENSP00000513372.1, ENST00000697649.1

  3. NM_006466.4 → NP_006457.2  DNA-directed RNA polymerase III subunit RPC6 isoform 1

    See identical proteins and their annotated locations for NP_006457.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL121893
    Consensus CDS
    CCDS13135.1
    UniProtKB/Swiss-Prot
    A8K4C7, O15319, Q9H1D9
    UniProtKB/TrEMBL
    Q53FI8
    Related
    ENSP00000366828.4, ENST00000377603.5
    Conserved Domains (1) summary
    pfam05158
    Location:12 → 315
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RNA

  1. NR_104209.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL121893
    Related
    ENST00000697656.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    18467390..18484646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439836.1 → XP_047295792.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

    Related
    ENSP00000513382.1, ENST00000697657.1

  2. XM_047439837.1 → XP_047295793.1  DNA-directed RNA polymerase III subunit RPC6 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TL53
    Related
    ENSP00000513376.1, ENST00000697652.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    18518490..18535746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322851.1 → XP_054178826.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

  2. XM_054322852.1 → XP_054178827.1  DNA-directed RNA polymerase III subunit RPC6 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TL53
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H1D9.1 GenPept UniProtKB/Swiss-Prot:Q9H1D9

Gene LinkOut

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