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Rfc4 replication factor C (activator 1) 4 [ Mus musculus (house mouse) ]

Gene ID: 106344, updated on 2-Nov-2024

Summary

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Official Symbol
Rfc4provided by MGI
Official Full Name
replication factor C (activator 1) 4provided by MGI
Primary source
MGI:MGI:2146571
See related
Ensembl:ENSMUSG00000022881 AllianceGenome:MGI:2146571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1; RFC37
Summary
Enables enzyme binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be located in nucleoplasm. Predicted to be part of Ctf18 RFC-like complex; DNA replication factor C complex; and Elg1 RFC-like complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer and heart. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 9.4), CNS E11.5 (RPKM 6.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Rfc4 in Genome Data Viewer
Location:
16 B1; 16 13.93 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22932698..22946480, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23113948..23127730, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene predicted gene, 26447 Neighboring gene predicted gene, 24616 Neighboring gene STARR-positive B cell enhancer ABC_E8623 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23165651-23165889 Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene predicted pseudogene 6630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Gray S, et al. Cell Rep, 2020 Jul 7. PMID 32640224, Free PMC Article
  2. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
  3. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. Westendorp B, et al. FASEB J, 2012 Jun. PMID 22403008
  4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
  5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
  
part_of Elg1 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Elg1 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 4
Names
activator 1 subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145480.1 → NP_663455.1  replication factor C subunit 4

    See identical proteins and their annotated locations for NP_663455.1

    Status: PROVISIONAL

    Source sequence(s)
    BC003335
    Consensus CDS
    CCDS37301.1
    UniProtKB/Swiss-Prot
    Q99J62
    UniProtKB/TrEMBL
    Q3UI84
    Related
    ENSMUSP00000023598.9, ENSMUST00000023598.15
    Conserved Domains (4) summary
    cd00009
    Location:55 → 201
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK00440
    Location:39 → 354
    rfc; replication factor C small subunit; Reviewed
    pfam08542
    Location:285 → 354
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:217 → 267
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22932698..22946480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J62.1 GenPept UniProtKB/Swiss-Prot:Q99J62

Gene LinkOut

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