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MDC1-AS1 MDC1 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 106478956, updated on 17-Sep-2024

Summary

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Official Symbol
MDC1-AS1provided by HGNC
Official Full Name
MDC1 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:39764
See related
Ensembl:ENSG00000224328 AllianceGenome:HGNC:39764
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDC1-AS
Expression
Broad expression in testis (RPKM 29.3), thyroid (RPKM 11.3) and 25 other tissues See more
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Genomic context

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See MDC1-AS1 in Genome Data Viewer
Location:
6p21.33
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30703067..30713184)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30567271..30577387)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30670844..30680961)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene nurim Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30668297-30668798 Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30683707-30684454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30685203-30685950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30687755-30688653 Neighboring gene tubulin beta class I Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30698119-30698743 Neighboring gene flotillin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30709349-30710229

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma. Yue H, et al. Biomed Pharmacother, 2016 Jul. PMID 27261595
  2. A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer. Xue Y, et al. Oncotarget, 2015 Jan 1. PMID 25514464, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MDC1-AS is a novel tumor suppressor through up-regulation of its antisense tumor-suppressing gene MDC1 in glioma.
    Title: MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Other Names

  • MDC1 antisense RNA 1 (non-protein coding)
  • XXbac-BPG27H4.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_133647.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL662797
    Related
    ENST00000442150.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30703067..30713184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2032572..2042688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2182808..2192924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1958919..1969035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    2013319..2023435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2047143..2057259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1958181..1968296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    2003853..2013969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30567271..30577387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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