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Rab31 RAB31, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 106572, updated on 28-Oct-2024

Summary

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Official Symbol
Rab31provided by MGI
Official Full Name
RAB31, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1914603
See related
Ensembl:ENSMUSG00000056515 AllianceGenome:MGI:1914603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab22B; 1700093E07Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of phagocytosis, engulfment. Located in early phagosome membrane and phagocytic cup. Is expressed in axial musculature; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human RAB31 (RAB31, member RAS oncogene family). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 24.0), cortex adult (RPKM 19.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Rab31 in Genome Data Viewer
Location:
17 E1.1; 17 35.03 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65958721..66079747, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65651726..65772752, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene STARR-seq mESC enhancer starr_43027 Neighboring gene ralA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10964 Neighboring gene predicted gene, 49870

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis. Qiu C, et al. Int J Biochem Cell Biol, 2022 Mar. PMID 35091093
  2. Rab31 is expressed in neural progenitor cells and plays a role in their differentiation. Chua CE, et al. FEBS Lett, 2014 Aug 25. PMID 24999186
  3. Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry. Luo L, et al. Proteomics, 2014 Jan. PMID 24259493
  4. Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome. Chua CE, et al. J Biol Chem, 2014 May 2. PMID 24644286, Free PMC Article
  5. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Lodhi IJ, et al. Cell Metab, 2007 Jan. PMID 17189207, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab31 promotes activation of hepatic stellate cells by accelerating TGF-beta receptor II complex endocytosis.
    Title: Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis.
  2. Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
    Title: Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
  3. a previously unrecognised role for Rab31 in influencing the differentiation and fate of neural progenitor cells
    Title: Rab31 is expressed in neural progenitor cells and plays a role in their differentiation.
  4. Rab22B is exceptionally enriched in nestin and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP)-positive mature astrocytes.
    Title: Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.
  5. Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell.
    Title: Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early phagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ras-related protein Rab-31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133685.2 → NP_598446.2  ras-related protein Rab-31

    See identical proteins and their annotated locations for NP_598446.2

    Status: VALIDATED

    Source sequence(s)
    AC139751, AC166058, AK051270, AK159095, BY761495
    Consensus CDS
    CCDS50166.1
    UniProtKB/Swiss-Prot
    Q8BKP0, Q921E2
    UniProtKB/TrEMBL
    Q3TXV4
    Related
    ENSMUSP00000068195.8, ENSMUST00000070673.9
    Conserved Domains (2) summary
    cd01860
    Location:6 → 168
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    pfam00071
    Location:8 → 168
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65958721..66079747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160241.1 → XP_036016134.1  ras-related protein Rab-31 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 125
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921E2.2 GenPept UniProtKB/Swiss-Prot:Q921E2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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