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Ankrd12 ankyrin repeat domain 12 [ Mus musculus (house mouse) ]

Gene ID: 106585, updated on 28-Oct-2024

Summary

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Official Symbol
Ankrd12provided by MGI
Official Full Name
ankyrin repeat domain 12provided by MGI
Primary source
MGI:MGI:1914357
See related
Ensembl:ENSMUSG00000034647 AllianceGenome:MGI:1914357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAC-1; ANCO-2; mKIAA0874; 2900001A12Rik
Summary
Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Orthologous to human ANKRD12 (ankyrin repeat domain 12). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 6.8), whole brain E14.5 (RPKM 5.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd12 in Genome Data Viewer
Location:
17 E1.1; 17 35.26 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66272698..66386242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65965703..66078804, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35550 Neighboring gene STARR-seq mESC enhancer starr_43037 Neighboring gene twisted gastrulation BMP signaling modulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E8691 Neighboring gene STARR-seq mESC enhancer starr_43040 Neighboring gene STARR-positive B cell enhancer ABC_E10965 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 Neighboring gene predicted gene, 23264 Neighboring gene STARR-seq mESC enhancer starr_43041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66456304-66456487 Neighboring gene STARR-positive B cell enhancer ABC_E10966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66460812-66460921 Neighboring gene WASH complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of novel ARF binding proteins by two-hybrid screening. Tompkins V, et al. Cell Cycle, 2006 Mar. PMID 16582619
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025572.1 → NP_001020743.1  ankyrin repeat domain-containing protein 12

    See identical proteins and their annotated locations for NP_001020743.1

    Status: VALIDATED

    Source sequence(s)
    AC119957, AC121299, AK122392, BC023046, CF553222, CF907970
    Consensus CDS
    CCDS28943.1
    UniProtKB/TrEMBL
    G5E893
    Related
    ENSMUSP00000039035.6, ENSMUST00000038116.13
    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66272698..66386242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523393.5 → XP_006523456.1  ankyrin repeat domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006523456.1

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006523397.5 → XP_006523460.1  ankyrin repeat domain-containing protein 12 isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:359 → 1142
    PTZ00121; MAEBL; Provisional
    COG0666
    Location:55 → 253
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:161 → 192
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:166 → 254
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_030249419.2 → XP_030105279.1  ankyrin repeat domain-containing protein 12 isoform X5

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006523396.5 → XP_006523459.1  ankyrin repeat domain-containing protein 12 isoform X2

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036160243.1 → XP_036016136.1  ankyrin repeat domain-containing protein 12 isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_036160245.1 → XP_036016138.1  ankyrin repeat domain-containing protein 12 isoform X6

    Conserved Domains (3) summary
    PTZ00121
    Location:335 → 1118
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:137 → 168
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:142 → 230
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_030249420.2 → XP_030105280.1  ankyrin repeat domain-containing protein 12 isoform X8

    Conserved Domains (1) summary
    PTZ00121
    Location:89 → 872
    PTZ00121; MAEBL; Provisional

  8. XM_006523399.5 → XP_006523462.1  ankyrin repeat domain-containing protein 12 isoform X7

    Conserved Domains (4) summary
    PTZ00121
    Location:359 → 1142
    PTZ00121; MAEBL; Provisional
    COG0666
    Location:55 → 253
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:161 → 192
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:166 → 254
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_006523395.4 → XP_006523458.1  ankyrin repeat domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006523458.1

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_030249418.2 → XP_030105278.1  ankyrin repeat domain-containing protein 12 isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:359 → 1142
    PTZ00121; MAEBL; Provisional
    COG0666
    Location:55 → 253
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:161 → 192
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:166 → 254
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_006523394.5 → XP_006523457.1  ankyrin repeat domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006523457.1

    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_030249417.1 → XP_030105277.1  ankyrin repeat domain-containing protein 12 isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:359 → 1142
    PTZ00121; MAEBL; Provisional
    COG0666
    Location:55 → 253
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:161 → 192
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:166 → 254
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_036160246.1 → XP_036016139.1  ankyrin repeat domain-containing protein 12 isoform X9

    Conserved Domains (1) summary
    PTZ00121
    Location:80 → 863
    PTZ00121; MAEBL; Provisional

  14. XM_036160244.1 → XP_036016137.1  ankyrin repeat domain-containing protein 12 isoform X4

    UniProtKB/TrEMBL
    G5E893
    Conserved Domains (3) summary
    PTZ00121
    Location:382 → 1165
    PTZ00121; MAEBL; Provisional
    sd00045
    Location:184 → 215
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:189 → 277
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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