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RNA18SN1 RNA, 18S ribosomal N1 [ Homo sapiens (human) ]

Gene ID: 106631781, updated on 10-Oct-2023

Summary

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Official Symbol
RNA18SN1provided by HGNC
Official Full Name
RNA, 18S ribosomal N1provided by HGNC
Primary source
HGNC:HGNC:53515
See related
AllianceGenome:HGNC:53515
Gene type
rRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNA18S4
Summary
45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene is a representative copy of the 18S ribosomal RNA on chromosome 21. [provided by RefSeq, Feb 2017]
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Genomic context

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See RNA18SN1 in Genome Data Viewer
Location:
21p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (8436876..8438744)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (3205318..3207186)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene microRNA 6724-4 Neighboring gene RNA, 45S pre-ribosomal N1 Neighboring gene microRNA 10396b Neighboring gene RNA, 5.8S ribosomal N1 Neighboring gene RNA, 28S ribosomal N1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defects in 18 S or 28 S rRNA processing activate the p53 pathway. Hölzel M, et al. J Biol Chem, 2010 Feb 26. PMID 20056613, Free PMC Article
  2. Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. Gonzalez IL, et al. Genomics, 2001 May 1. PMID 11350117
  3. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. Yu S, et al. Genome Biol Evol, 2016 Dec 31. PMID 27797956, Free PMC Article
  4. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. McStay B. Genes Dev, 2016 Jul 15. PMID 27474438, Free PMC Article
  5. The Epigenetic Pathways to Ribosomal DNA Silencing. Srivastava R, et al. Microbiol Mol Biol Rev, 2016 Sep. PMID 27250769, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • 18S rRNA 4
  • RNA, 18S ribosomal 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_145820.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    FP236383

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    8436876..8438744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160023.1 Reference GRCh38.p14 PATCHES

    Range
    484001..485869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    3205318..3207186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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