LOC106783505 - nonconserved acetylation island sequence 45 enhancer
This region can function as an enhancer in human Jurkat T cells. The spatially equivalent or corresponding region in mouse, which is not conserved at the sequence level, can also function as an enhancer in mouse EL4 T cells. The chromatin structure of this region represents a histone acetylation island in human T cells based on the diacetylation of histone H3 at lysines 9 and 14. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NCBI Orthologs
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