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LOC106865369 nucleoporin 98kDa recombination region [ Homo sapiens (human) ]

Gene ID: 106865369, updated on 10-Oct-2023

Summary

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Gene symbol
LOC106865369
Gene description
nucleoporin 98kDa recombination region
Gene type
biological region
Feature type(s)
misc_recomb: mitotic
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region is known to undergo recombination with a variety of translocation and inversion partners, resulting in multiple different chimeric transcripts. Many of these chimeras have been implicated in tumorigenesis. Those regions where translocation breakpoints have been mapped on the genomic sequence are represented here. [provided by RefSeq, Mar 2017]
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Genomic context

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Location:
11q15.5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3731687..3753315)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3797026..3818651)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3752917..3774545)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3717665-3717885 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:3723311-3723810 Neighboring gene RNA, U6 small nuclear 1143, pseudogene Neighboring gene MPRA-validated peak1178 silencer Neighboring gene MPRA-validated peak1179 silencer Neighboring gene RNA, U7 small nuclear 50 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3811721-3812640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3812641-3813558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3084 Neighboring gene uncharacterized LOC124902618 Neighboring gene post-GPI attachment to proteins 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The first Korean case of childhood acute myeloid leukemia with inv(11)(p15q22)/NUP98-DDX10 rearrangement: a rare but recurrent genetic abnormality. Choi R, et al. Ann Lab Med, 2014 Nov. PMID 25368827, Free PMC Article
  2. Inv(11)(p15q22)/NUP98-DDX10 fusion and isoforms in a new case of de novo acute myeloid leukemia. Gorello P, et al. Cancer Genet, 2013 Mar. PMID 23522748
  3. Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia. Morerio C, et al. Cancer Genet Cytogenet, 2006 Dec. PMID 17116492
  4. NUP98 is fused to topoisomerase (DNA) IIbeta 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15). Nebral K, et al. Clin Cancer Res, 2005 Sep 15. PMID 16166424
  5. Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia. Yamamoto M, et al. Cancer Genet Cytogenet, 2005 Mar. PMID 15721630

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • NUP98 recombination region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046316.1 

    Range
    101..21729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3731687..3753315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3797026..3818651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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