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FUT9 fucosyltransferase 9 [ Homo sapiens (human) ]

Gene ID: 10690, updated on 2-Nov-2024

Summary

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Official Symbol
FUT9provided by HGNC
Official Full Name
fucosyltransferase 9provided by HGNC
Primary source
HGNC:HGNC:4020
See related
Ensembl:ENSG00000172461 MIM:606865; AllianceGenome:HGNC:4020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fuc-TIX
Summary
The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Expression
Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See FUT9 in Genome Data Viewer
Location:
6q16.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (96015974..96215612)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (97186913..97387800)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96463850..96663488)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:96250823-96251589 Neighboring gene uncharacterized LOC107986626 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:96425470-96426669 Neighboring gene uncharacterized LOC105377905 Neighboring gene keratin 18 pseudogene 50 Neighboring gene UFL1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24840 Neighboring gene RNA, 7SL, cytoplasmic 797, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24841 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:96967525-96968398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:96968399-96969270 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:96969271-96970142 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:96970143-96971014 Neighboring gene UFM1 specific ligase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9. Kadirvelraj R, et al. Nat Chem Biol, 2023 Aug. PMID 37202521, Free PMC Article
  2. Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization. Kaneko M, et al. Cytogenet Cell Genet, 1999. PMID 10575236
  3. FUT4 and FUT9 genes are expressed early in human embryogenesis. Cailleau-Thomas A, et al. Glycobiology, 2000 Aug. PMID 10929005
  4. [Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]. Li H, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Nov. PMID 12417923
  5. A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Sikora M, et al. Hum Mol Genet, 2009 Aug 15. PMID 19460885

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
    Title: ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
  2. FUT9 silencing decreases the expression of the colorectal cancer TIC marker CD44 and the level of the OCT4 transcription factor, which is known to support cancer stemness.
    Title: An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.
  3. N-glycosylation of human alpha1,3-fucosyltransferase IX is required for enzyme stability and activity.
    Title: N-glycosylations of human α1,3-fucosyltransferase IX are required for full enzyme activity.
  4. FUT9 plays a significant role during human, but not mouse, E-selectin-mediated cell adhesion.
    Title: Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.
  5. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
    Title: Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. A single nucleotide polymorphism in FUT9, rs3811070, was significantly associated with placental malaria infection.
    Title: A variant in the gene FUT9 is associated with susceptibility to placental malaria infection.
  8. FUT9 was found to be a trans-Golgi and trans-Golgi network (TGN) glycosyltransferase from confocal immunofluorescence co-localization with the markers of the secretory pathway beta4-galactosyltransferase (trans-Golgi and TGN) and TGN-46 (TGN)
    Title: Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization.
  9. FUTIX plays a key role in the synthesis of Lex groups of CEACAM1
    Title: CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues.
  10. Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile
    Title: Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables fucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-fucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Lewis x epitope biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-glycan fucosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuronal stem cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in polysaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Names
alpha-(1,3)-fucosyltransferase 9
fucT-IX
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
fucosyltransferase IX
galactoside 3-L-fucosyltransferase
NP_006572.2
XP_011533687.1
XP_016865677.1
XP_016865679.1
XP_047274044.1
XP_047274045.1
XP_054210029.1
XP_054210030.1
XP_054210031.1
XP_054210032.1
XP_054210033.1
XP_054210034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006581.4 → NP_006572.2  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

    See identical proteins and their annotated locations for NP_006572.2

    Status: REVIEWED

    Source sequence(s)
    AL512406, BC036101, CK299829, CK904220
    Consensus CDS
    CCDS5033.1
    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231
    Related
    ENSP00000302599.4, ENST00000302103.6
    Conserved Domains (2) summary
    pfam00852
    Location:185 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62 → 169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    96015974..96215612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418089.1 → XP_047274045.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231

  2. XM_047418088.1 → XP_047274044.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231

  3. XM_017010190.2 → XP_016865679.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62 → 169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  4. XM_011535385.3 → XP_011533687.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    See identical proteins and their annotated locations for XP_011533687.1

    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62 → 169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  5. XM_017010188.2 → XP_016865677.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q5T0W4, Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62 → 169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    97186913..97387800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354058.1 → XP_054210033.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2

  2. XM_054354056.1 → XP_054210031.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2

  3. XM_054354059.1 → XP_054210034.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2

  4. XM_054354057.1 → XP_054210032.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2

  5. XM_054354054.1 → XP_054210029.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2

  6. XM_054354055.1 → XP_054210030.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/TrEMBL
    Q5Q0U2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y231.2 GenPept UniProtKB/Swiss-Prot:Q9Y231

Gene LinkOut

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