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LOC107032760 origin of replication in promoter/intron 1 of HPRT1 [ Homo sapiens (human) ]

Gene ID: 107032760, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107032760
Gene description
origin of replication in promoter/intron 1 of HPRT1
Gene type
biological region
Feature type(s)
regulatory: matrix_attachment_region
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains multiple sequences that can function as replication origins, including a site that represents a local peak of nascent strand synthesis. This origin may show reduced activity when the HPRT (hypoxanthine phosphoribosyltransferase 1) gene promoter is silenced, such as on the inactive X chromosome. This region also contains sequence that binds to nuclear matrix preparations and may represent a scaffold/matrix attachment region. [provided by RefSeq, Dec 2015]
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Genomic context

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Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (134460082..134465691)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (132785245..132790854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133594112..133599721)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NT5DC1 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:133515535-133515735 Neighboring gene PHD finger protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21009 Neighboring gene hypoxanthine phosphoribosyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21010 Neighboring gene ribosomal protein L36a pseudogene 54 Neighboring gene microRNA 450b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. Cohen SM, et al. Genomics, 2004 Sep. PMID 15498455
  2. Mapping of an origin of DNA replication near the transcriptional promoter of the human HPRT gene. Cohen SM, et al. J Cell Biochem, 2002. PMID 11948690
  3. On the relationship of matrix association and DNA replication. Brylawski BP, et al. Crit Rev Eukaryot Gene Expr, 2000. PMID 10813397
  4. Yeast ARS function and nuclear matrix association coincide in a short sequence from the human HPRT locus. Sykes RC, et al. Mol Gen Genet, 1988 May. PMID 2841570
  5. Asynchronous replication of homologous loci on human active and inactive X chromosomes. Schmidt M, et al. Proc Natl Acad Sci U S A, 1990 May. PMID 2339112, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046339.1 

    Range
    101..5710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    134460082..134465691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    132785245..132790854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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