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Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 [ Mus musculus (house mouse) ]

Gene ID: 107141, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp2c50provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily c, polypeptide 50provided by MGI
Primary source
MGI:MGI:2147497
See related
Ensembl:ENSMUSG00000054827 AllianceGenome:MGI:2147497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arachidonate epoxygenase activity and linoleic acid epoxygenase activity. Acts upstream of or within arachidonate metabolic process and linoleic acid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in alimentary system and liver. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; carcinoma (multiple); end stage renal disease; glucose metabolism disease (multiple); and hypertension (multiple). Orthologous to several human genes including CYP2C18 (cytochrome P450 family 2 subfamily C member 18); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C8 (cytochrome P450 family 2 subfamily C member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 157.0) See more
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Genomic context

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See Cyp2c50 in Genome Data Viewer
Location:
19 C3; 19 34.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40078123..40102399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40089679..40113955)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2. subfamily c, polypeptide 37 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 54 Neighboring gene STARR-seq mESC enhancer starr_46126 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 70 Neighboring gene nuclear receptor subfamily 1, group D, member 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Zhang D, et al. Mol Metab, 2024 Jul. PMID 38740087, Free PMC Article
  2. Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Wang H, et al. Mol Pharmacol, 2004 May. PMID 15102943
  3. Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements. Kasai F, et al. Cytogenet Genome Res, 2007. PMID 18160786
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH.
    Title: Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables caffeine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables estrogen 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables linoleic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retinoic acid 4-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arachidonate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450 2C50
Names
CYPIIC50
cytochrome P450, 2c50
NP_001161347.1
NP_001161349.1
NP_598905.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167875.1 → NP_001161347.1  cytochrome P450 2C50 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC148014, AW111073, AY206873, BY086770
    Consensus CDS
    CCDS50433.1
    UniProtKB/TrEMBL
    Q9DBD9
    Related
    ENSMUSP00000068039.7, ENSMUST00000068094.13
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 428
    p450; Cytochrome P450

  2. NM_001167877.1 → NP_001161349.1  cytochrome P450 2C50 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC148014, AK149466, BY086770
    Related
    ENSMUST00000124391.2
    Conserved Domains (1) summary
    cl12078
    Location:30 → 215
    p450; Cytochrome P450

  3. NM_134144.2 → NP_598905.2  cytochrome P450 2C50 isoform 1

    See identical proteins and their annotated locations for NP_598905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC148014, AW111073, AY206873, BY086770
    Consensus CDS
    CCDS29801.1
    UniProtKB/Swiss-Prot
    E9QPJ0, Q6XVG3, Q80X43, Q91X77
    UniProtKB/TrEMBL
    Q9DBD9
    Related
    ENSMUSP00000079065.3, ENSMUST00000080171.3
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 487
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40078123..40102399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X77.2 GenPept UniProtKB/Swiss-Prot:Q91X77

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