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AOX3P-AOX2P AOX3P-AOX2P readthrough, transcribed pseudogene [ Homo sapiens (human) ]

Gene ID: 107161151, updated on 17-Aug-2024

Summary

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Official Symbol
AOX3P-AOX2Pprovided by HGNC
Official Full Name
AOX3P-AOX2P readthrough, transcribed pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:53766
See related
AllianceGenome:HGNC:53766
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AOX3/AOX3L1
Summary
This locus represents naturally-occurring readthrough transcription between two unprocessed unitary pseudogenes, AOX3P (aldehyde oxidase 3, pseudogene) and AOX2P (aldehyde oxidase 2 pseudogene). The individual pseudogene loci are not curated as transcribed regions. Readthrough transcripts contains disrupted open reading frames, relative to functional homologs, and likely do not encode functional proteins. [provided by RefSeq, Jan 2016]
Expression
Biased expression in bone marrow (RPKM 1.1), testis (RPKM 0.1) and 2 other tissues See more
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Genomic context

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See AOX3P-AOX2P in Genome Data Viewer
Location:
2q33.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (200695723..200794915)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201179102..201278339)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201560446..201659638)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene shugoshin 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:201473343-201474542 Neighboring gene aldehyde oxidase 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:201513174-201514373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16961 Neighboring gene aldehyde oxidase 3, pseudogene Neighboring gene long intergenic non-protein coding RNA 1792 Neighboring gene aldehyde oxidase 2, pseudogene Neighboring gene AOX3P-AOX2P intron CAGE-defined mid-level expression enhancer Neighboring gene RNA, U1 small nuclear 133, pseudogene Neighboring gene BZW1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201676955-201677470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201677471-201677986 Neighboring gene RNA, U6 small nuclear 31, pseudogene Neighboring gene basic leucine zipper and W2 domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_135011.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) represents the longer transcript.
    Source sequence(s)
    AC007163, AY245868, DB150752, DB344122, DV080673, JX431286

  2. NR_135012.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) lacks an alternate exon in the 5' region, resulting in a shorter transcript than variant B.
    Source sequence(s)
    AC007163, AY245868, DB150752, DB344122, DV080673, JX431285

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    200695723..200794915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201179102..201278339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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