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LOC107181288 origin of replication in promoter of G6PD [ Homo sapiens (human) ]

Gene ID: 107181288, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107181288
Gene description
origin of replication in promoter of G6PD
Gene type
biological region
Feature type(s)
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains an origin of DNA replication overlapping the promoter region of the glucose-6-phosphate dehydrogenase (G6PD) gene. Replication timing of this region may correlate to X inactivation status; it may replicate earlier on an active X allele. [provided by RefSeq, Feb 2016]
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Genomic context

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Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154546511..154547759)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152782894..152784142)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153774726..153775974)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 697, pseudogene Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene uncharacterized LOC124905229 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153743824-153744447 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153744448-153745070 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153745046-153745202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30065 Neighboring gene Sharpr-MPRA regulatory region 11639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153762224-153762818 Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene G6PD and IKBKG intron CAGE-defined low expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153774097-153774640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30067 Neighboring gene inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Neighboring gene IKBKG recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153792215-153792716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153792717-153793216 Neighboring gene IKBKG downstream recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153798001-153798800 Neighboring gene family with sequence similarity 223 member A Neighboring gene activating transcription factor 4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and gene content in 52 kb including and centromeric to the G6PD gene in Xq28. Zollo M, et al. DNA Seq, 1995. PMID 8746455
  2. Complete reactivation of X chromosomes from human chorionic villi with a switch to early DNA replication. Migeon BR, et al. Proc Natl Acad Sci U S A, 1986 Apr. PMID 3457382, Free PMC Article
  3. Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase. Martini G, et al. EMBO J, 1986 Aug. PMID 2428611, Free PMC Article
  4. The CpG island in the 5' region of the G6PD gene of man and mouse. Toniolo D, et al. Gene, 1991 Jun 30. PMID 1874446
  5. Same origins of DNA replication function on the active and inactive human X chromosomes. Cohen SM, et al. J Cell Biochem, 2003 Apr 1. PMID 12616531

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046714.1 

    Range
    101..1349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154546511..154547759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152782894..152784142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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