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Lpxn leupaxin [ Mus musculus (house mouse) ]

Gene ID: 107321, updated on 2-Nov-2024

Summary

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Official Symbol
Lpxnprovided by MGI
Official Full Name
leupaxinprovided by MGI
Primary source
MGI:MGI:2147677
See related
Ensembl:ENSMUSG00000024696 AllianceGenome:MGI:2147677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LDPL; 4933402K05Rik; A530083L21Rik
Summary
Enables transcription coregulator activity. Involved in negative regulation of B cell receptor signaling pathway and regulation of cell adhesion mediated by integrin. Located in focal adhesion; nucleus; and podosome. Is expressed in central nervous system; genitourinary system; and thymus. Orthologous to human LPXN (leupaxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 12.1), thymus adult (RPKM 11.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Lpxn in Genome Data Viewer
Location:
19 A; 19 8.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12773251..12811177)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12795887..12833813)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene kidney expressed gene 1 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45598 Neighboring gene predicted readthrough transcript (NMD candidate), 44505 Neighboring gene ciliary neurotrophic factor Neighboring gene zinc finger protein 91 Neighboring gene STARR-positive B cell enhancer ABC_E11024 Neighboring gene STARR-positive B cell enhancer ABC_E4268 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12870708-12870906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12871167-12871368 Neighboring gene STARR-positive B cell enhancer ABC_E8742 Neighboring gene STARR-positive B cell enhancer ABC_E7636 Neighboring gene ribosomal protein lateral stalk subunit P1, retrotransposed Neighboring gene olfactory receptor family 5 subfamily B member 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leupaxin Expression Is Dispensable for B Cell Immune Responses. Bonaud A, et al. Front Immunol, 2020. PMID 32269569, Free PMC Article
  2. Association of leupaxin with Src in osteoclasts. Sahu SN, et al. Am J Physiol Cell Physiol, 2007 Jan. PMID 16914530
  3. A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability. Klapproth S, et al. J Cell Biol, 2019 Oct 7. PMID 31537712, Free PMC Article
  4. Leupaxin binds to PEST domain tyrosine phosphatase PEP. Watanabe N, et al. Mol Cell Biochem, 2005 Jan. PMID 15786712
  5. NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. Huntington ND, et al. J Immunol, 2007 Apr 15. PMID 17404256

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leupaxin Expression Is Dispensable for B Cell Immune Responses.
    Title: Leupaxin Expression Is Dispensable for B Cell Immune Responses.
  2. The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.
    Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
  3. leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling.
    Title: LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
  4. Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.
    Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
  5. Leupaxin plays an inhibitory role in BCR signaling and B cell function.
    Title: Leupaxin negatively regulates B cell receptor signaling.
  6. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
    Title: Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.
  7. Association of the scaffold protein LPXN with Src adds further complexity to the organization of the podosomal signaling complex in osteoclasts.
    Title: Association of leupaxin with Src in osteoclasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leupaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361971.1 → NP_001348900.1  leupaxin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK077085, AV257675
    Consensus CDS
    CCDS89350.1
    UniProtKB/TrEMBL
    A0A494B990
    Related
    ENSMUSP00000157548.2, ENSMUST00000235690.2
    Conserved Domains (2) summary
    cd09339
    Location:233 → 284
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:54 → 108
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_134152.4 → NP_598913.1  leupaxin isoform 1

    See identical proteins and their annotated locations for NP_598913.1

    Status: VALIDATED

    Source sequence(s)
    AC135633, AC150901
    Consensus CDS
    CCDS29638.1
    UniProtKB/Swiss-Prot
    Q99N69
    UniProtKB/TrEMBL
    Q8R355
    Related
    ENSMUSP00000025601.7, ENSMUST00000025601.8
    Conserved Domains (2) summary
    cd09339
    Location:329 → 380
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:150 → 204
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    12773251..12811177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250687.1 → XP_030106547.1  leupaxin isoform X1

    UniProtKB/TrEMBL
    A0A494B990
    Conserved Domains (2) summary
    cd09339
    Location:233 → 284
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:54 → 108
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_030250689.2 → XP_030106549.1  leupaxin isoform X1

    UniProtKB/TrEMBL
    A0A494B990
    Conserved Domains (2) summary
    cd09339
    Location:233 → 284
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:54 → 108
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_030250688.2 → XP_030106548.1  leupaxin isoform X1

    UniProtKB/TrEMBL
    A0A494B990
    Conserved Domains (2) summary
    cd09339
    Location:233 → 284
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:54 → 108
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N69.2 GenPept UniProtKB/Swiss-Prot:Q99N69

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