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Gimap4 GTPase, IMAP family member 4 [ Mus musculus (house mouse) ]

Gene ID: 107526, updated on 14-May-2024

Summary

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Official Symbol
Gimap4provided by MGI
Official Full Name
GTPase, IMAP family member 4provided by MGI
Primary source
MGI:MGI:1349656
See related
Ensembl:ENSMUSG00000054435 AllianceGenome:MGI:1349656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ian1; Ian-1; Imap4; E430007K16Rik
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in spleen adult (RPKM 17.4), mammary gland adult (RPKM 13.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Gimap4 in Genome Data Viewer
Location:
6 B2.3; 6 23.66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48661453..48668996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48684578..48692062)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44262 Neighboring gene predicted gene, 46958 Neighboring gene GTPase, IMAP family member 9 Neighboring gene STARR-positive B cell enhancer ABC_E3653 Neighboring gene GTPase, IMAP family member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8100 Neighboring gene STARR-positive B cell enhancer ABC_E6427 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48668564-48668753 Neighboring gene GTPase, IMAP family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gimap4 accelerates T-cell death. Schnell S, et al. Blood, 2006 Jul 15. PMID 16569770
  2. Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Ralpha449F knock-in T cell progenitors. Duthie KA, et al. Mol Cell Proteomics, 2007 Oct. PMID 17602185
  3. Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants. Poirier GM, et al. J Immunol, 1999 Nov 1. PMID 10528200
  4. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. Stamm O, et al. Gene, 2002 Jan 9. PMID 11814688
  5. IAN family critically regulates survival and development of T lymphocytes. Nitta T, et al. PLoS Biol, 2006 Apr. PMID 16509771, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC11734

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTPase IMAP family member 4
Names
immune associated nucleotide 1
immunity-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243199.1 → NP_001230128.1  GTPase IMAP family member 4 isoform c

    See identical proteins and their annotated locations for NP_001230128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC153894, BG092483
    Consensus CDS
    CCDS57423.1
    UniProtKB/Swiss-Prot
    Q99JY3
    Related
    ENSMUSP00000068398.8, ENSMUST00000067506.14
    Conserved Domains (1) summary
    cd01852
    Location:31 → 212
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

  2. NM_001243200.1 → NP_001230129.1  GTPase IMAP family member 4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AC153894, BG092483
    Consensus CDS
    CCDS57421.1
    UniProtKB/TrEMBL
    D3YWB5
    Related
    ENSMUSP00000112530.2, ENSMUST00000118802.8
    Conserved Domains (1) summary
    cl21455
    Location:49 → 102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001243201.1 → NP_001230130.1  GTPase IMAP family member 4 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment that spans both the central and 3' coding regions, and which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC153894, BC098226, BG092483
    Consensus CDS
    CCDS57422.1
    UniProtKB/TrEMBL
    D3Z3F3
    Related
    ENSMUSP00000113989.2, ENSMUST00000119575.8
    Conserved Domains (1) summary
    cl21455
    Location:31 → 48
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_174990.4 → NP_778155.2  GTPase IMAP family member 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC153894, BG092483, CA576036
    Consensus CDS
    CCDS20110.1
    UniProtKB/Swiss-Prot
    D3YTN4, Q99JY3
    Related
    ENSMUSP00000087524.5, ENSMUST00000090070.6
    Conserved Domains (1) summary
    pfam04548
    Location:31 → 230
    AIG1; AIG1 family

  5. NM_175048.3 → NP_778213.2  GTPase IMAP family member 4 isoform b

    See identical proteins and their annotated locations for NP_778213.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks both an in-frame segment in the central coding region and a large segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA543119, AA795946, AC153894, BG092483
    Consensus CDS
    CCDS39481.2
    UniProtKB/TrEMBL
    D3Z7Q4
    Related
    ENSMUSP00000113016.2, ENSMUST00000121957.8
    Conserved Domains (1) summary
    cl21455
    Location:49 → 84
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48661453..48668996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165721.1 → XP_036021614.1  GTPase IMAP family member 4 isoform X1

    Conserved Domains (1) summary
    cd01852
    Location:31 → 212
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JY3.2 GenPept UniProtKB/Swiss-Prot:Q99JY3

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