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Aldh1l1 aldehyde dehydrogenase 1 family, member L1 [ Mus musculus (house mouse) ]

Gene ID: 107747, updated on 28-Oct-2024

Summary

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Official Symbol
Aldh1l1provided by MGI
Official Full Name
aldehyde dehydrogenase 1 family, member L1provided by MGI
Primary source
MGI:MGI:1340024
See related
Ensembl:ENSMUSG00000030088 AllianceGenome:MGI:1340024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FDH; Fthfd; Neut2; 1810048F20Rik
Summary
Enables formyltetrahydrofolate dehydrogenase activity. Involved in 10-formyltetrahydrofolate catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 382.3), kidney adult (RPKM 107.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Aldh1l1 in Genome Data Viewer
Location:
6 D1; 6 40.16 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90527751..90576153)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90550768..90599171)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 100 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene predicted gene, 53295 Neighboring gene Kruppel-like transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene STARR-positive B cell enhancer ABC_E8115 Neighboring gene predicted gene 15756 Neighboring gene solute carrier family 41, member 3 Neighboring gene predicted gene, 53296 Neighboring gene IQ motif and Sec7 domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E8116 Neighboring gene STARR-seq mESC enhancer starr_16629 Neighboring gene STARR-positive B cell enhancer ABC_E6454 Neighboring gene STARR-positive B cell enhancer ABC_E10393 Neighboring gene VISTA enhancer mm1470 Neighboring gene STARR-positive B cell enhancer ABC_E10394 Neighboring gene ribosomal protein L21, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered protein expression detected in the F1 offspring of male mice exposed to fission neutrons. Giometti CS, et al. Mutat Res, 1994 Jan. PMID 7506389
  2. PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. Tang J, et al. J Biol Chem, 2000 Mar 17. PMID 10713084
  3. Disruption of histidine catabolism in NEUT2 mice. Cook RJ. Arch Biochem Biophys, 2001 Aug 15. PMID 11488596
  4. The astrocyte marker Aldh1L1 does not reliably label enteric glial cells. Boesmans W, et al. Neurosci Lett, 2014 Apr 30. PMID 24589880
  5. Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko NI, et al. Sci Rep, 2019 Oct 17. PMID 31624291, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.
    Title: A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.
  2. Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.
    Title: Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.
  3. Collectively, MNSFbeta/FDH complex formation may positively regulate apoptosis in thymocytes.
    Title: Ubiquitin-like protein MNSFβ covalently binds to cytosolic 10-formyltetrahydrofolate dehydrogenase and regulates thymocyte function.
  4. Aldh1L1 is not a suitable marker for enteric glial cells.
    Title: The astrocyte marker Aldh1L1 does not reliably label enteric glial cells.
  5. This study demonistrated that Aldh1L1 is expressed by postnatal neural stem cells in mice.
    Title: Aldh1L1 is expressed by postnatal neural stem cells in vivo.
  6. These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.
    Title: The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables formyltetrahydrofolate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formyltetrahydrofolate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables formyltetrahydrofolate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 10-formyltetrahydrofolate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 10-formyltetrahydrofolate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic 10-formyltetrahydrofolate dehydrogenase
Names
10-FTHFDH
10-formyltetrahydrofolate dehydrogenase
aldehyde dehydrogenase family 1 member L1
formyltetrahydrofolate dehydrogenase
NP_001343341.1
NP_081682.1
XP_030110912.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356412.1 → NP_001343341.1  cytosolic 10-formyltetrahydrofolate dehydrogenase

    Status: VALIDATED

    Source sequence(s)
    AC122050
    Consensus CDS
    CCDS20361.1
    UniProtKB/Swiss-Prot
    Q8R0Y6
    UniProtKB/TrEMBL
    Q8CIF2
    Related
    ENSMUSP00000032175.9, ENSMUST00000032175.11
    Conserved Domains (4) summary
    cd07140
    Location:417 → 902
    ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
    cd08647
    Location:1 → 203
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:206 → 306
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
    pfam00550
    Location:325 → 391
    PP-binding; Phosphopantetheine attachment site

  2. NM_027406.2 → NP_081682.1  cytosolic 10-formyltetrahydrofolate dehydrogenase

    See identical proteins and their annotated locations for NP_081682.1

    Status: VALIDATED

    Source sequence(s)
    AC122050
    Consensus CDS
    CCDS20361.1
    UniProtKB/Swiss-Prot
    Q8R0Y6
    UniProtKB/TrEMBL
    Q8CIF2
    Related
    ENSMUSP00000114304.2, ENSMUST00000130418.8
    Conserved Domains (4) summary
    cd07140
    Location:417 → 902
    ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
    cd08647
    Location:1 → 203
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:206 → 306
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
    pfam00550
    Location:325 → 391
    PP-binding; Phosphopantetheine attachment site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90527751..90576153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255052.2 → XP_030110912.1  cytosolic 10-formyltetrahydrofolate dehydrogenase isoform X1

    Conserved Domains (3) summary
    cd07140
    Location:132 → 617
    ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
    pfam00550
    Location:40 → 106
    PP-binding; Phosphopantetheine attachment site
    cl14785
    Location:1 → 21
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0Y6.1 GenPept UniProtKB/Swiss-Prot:Q8R0Y6

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