U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pom121 nuclear pore membrane protein 121 [ Mus musculus (house mouse) ]

Gene ID: 107939, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pom121provided by MGI
Official Full Name
nuclear pore membrane protein 121provided by MGI
Primary source
MGI:MGI:2137624
See related
Ensembl:ENSMUSG00000053293 AllianceGenome:MGI:2137624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0618; 2610027A18Rik
Summary
Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus; nuclear pore organization; and protein import into nucleus. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of nuclear pore. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to several human genes including POM121 (POM121 transmembrane nucleoporin) and POM121C (POM121 transmembrane nucleoporin C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 46.8), thymus adult (RPKM 22.0) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pom121 in Genome Data Viewer
Location:
5 G2; 5 75.16 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135404994..135433587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135376140..135404841, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E9263 Neighboring gene tripartite motif-containing 50 Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene microRNA 7033 Neighboring gene huntingtin interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10357 Neighboring gene STARR-seq mESC enhancer starr_14578 Neighboring gene STARR-positive B cell enhancer ABC_E434 Neighboring gene predicted gene, 52790 Neighboring gene C-C motif chemokine ligand 26

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine. Wang SM, et al. Autophagy, 2023 Jan. PMID 35507432, Free PMC Article
  2. POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation. Ge W, et al. Exp Cell Res, 2019 Apr 15. PMID 30802453
  3. Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans. Olsson M, et al. Exp Cell Res, 2004 Jan 15. PMID 14697343
  4. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
  5. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, et al. Genomics, 2000 Oct 1. PMID 11013070

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
    Title: Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear pore organization ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear envelope pore membrane protein POM 121
Names
nucleoporin Nup121
pore membrane protein of 121 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148932.2 → NP_683734.2  nuclear envelope pore membrane protein POM 121

    See identical proteins and their annotated locations for NP_683734.2

    Status: VALIDATED

    Source sequence(s)
    AC024608, BC053101, CF545814, CJ306468, W44309
    Consensus CDS
    CCDS51662.1
    UniProtKB/Swiss-Prot
    Q7TSH5, Q8K3Z9
    UniProtKB/TrEMBL
    Q3U425, Q6A036
    Related
    ENSMUSP00000106801.3, ENSMUST00000111171.6
    Conserved Domains (1) summary
    pfam15229
    Location:292 → 527
    POM121; POM121 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135404994..135433587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504334.4 → XP_006504397.1  nuclear envelope pore membrane protein POM 121 isoform X1

    UniProtKB/TrEMBL
    Q6A036
    Conserved Domains (3) summary
    PHA03247
    Location:182 → 467
    PHA03247; large tegument protein UL36; Provisional
    PTZ00473
    Location:829 → 930
    PTZ00473; Plasmodium Vir superfamily; Provisional
    pfam15229
    Location:52 → 287
    POM121; POM121 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3Z9.2 GenPept UniProtKB/Swiss-Prot:Q8K3Z9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous