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Sox10-mcs1c/2 MCS1C/MCS2 enhancer region 5' of Sox10 [ Mus musculus (house mouse) ]

Gene ID: 107966123, updated on 9-Aug-2024

Summary

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Gene symbol
Sox10-mcs1c/2
Gene description
MCS1C/MCS2 enhancer region 5' of Sox10
Gene type
biological region
Feature type(s)
protein_bind
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U5; MCS2; MCS1C; Rr366667; Sox10-MCS2; Sox10-MCS1C
Summary
This region contains conserved enhancer elements located upstream of the SRY-box 10 (Sox10) gene. These elements can drive expression of a transgene in tissues that express Sox10, including the ganglia, otic vesicle, and Schwann cells. [provided by RefSeq, Sep 2016]
Orthologs
human all
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Genomic context

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See Sox10-mcs1c/2 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79048547..79050741)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79164347..79166541)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene D6 enhancer downstream of Sox10 Neighboring gene SRY (sex determining region Y)-box 10 Neighboring gene predicted gene 10863 Neighboring gene predicted gene, 53902 Neighboring gene Sox10 multiple-species conserved sequence 4 Neighboring gene Sox10 multiple-species conserved sequence 5 Neighboring gene Sox10 multiple-species conserved sequence 7 Neighboring gene Sox10 multiple-species conserved sequence 8 Neighboring gene STARR-seq mESC enhancer starr_39171 Neighboring gene predicted gene, 52189 Neighboring gene Sox10 multiple-species conserved sequence 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Werner T, et al. Nucleic Acids Res, 2007. PMID 17897962, Free PMC Article
  2. Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. Antonellis A, et al. PLoS Genet, 2008 Sep 5. PMID 18773071, Free PMC Article
  3. Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Deal KK, et al. Dev Dyn, 2006 May. PMID 16586440

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • Sox10 multiple-species conserved sequence 1C
  • Sox10 multiple-species conserved sequence 2
  • regulatory region 366667

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050695.1 

    Range
    101..2295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79048547..79050741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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