SMANTIS SMARCA4 interacting SWI/SNF chromatin remodeling complex scaffold lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: SMANTISprovided by HGNC
Official Full Name: SMARCA4 interacting SWI/SNF chromatin remodeling complex scaffold lncRNAprovided by HGNC
Primary source: HGNC:HGNC:54417
See related: Ensembl:ENSG00000288869 AllianceGenome:HGNC:54417
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: n342419; ANXA4-AS
Expression: Broad expression in gall bladder (RPKM 6.4), duodenum (RPKM 3.3) and 21 other tissues See more
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Genomic context

Location:: 2p13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (69789549..69798998, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (69801827..69811273, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (70016681..70026130, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions.
Title: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions.
LncRNA MANTIS is inducible by laminar flow and statins through transcription factors KLF2 and KLF4. Loss of MANTIS increased endothelial monocyte adhesion in an ICAM-1-dependent manner. Gene expression and functional responses of endothelial cells to laminar flow and statins are dependent on MANTIS.
Title: Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.
Authors describe that lncRNA MANTIS (alias AK125871) is controlled by histone demethylase JARID1B and important to facilitate endothelial angiogenic gene expression and nucleosome remodelling by interaction and promotion of BRG1. The lncRNA acts through its Alu element and is required for spheroid outgrowth, tube formation, misregulated in pulmonary hypertension and glioblastoma and inducible with laminar flow.
Title: Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_164153.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC019206
NR_164155.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC019206

Related

ENST00000686342.3