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B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 108105, updated on 2-Nov-2024

Summary

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Official Symbol
B3gnt5provided by MGI
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5provided by MGI
Primary source
MGI:MGI:2137302
See related
Ensembl:ENSMUSG00000022686 AllianceGenome:MGI:2137302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
beta3GnT5
Summary
Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity and lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity. Predicted to be involved in central nervous system development and protein O-linked glycosylation. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 4.8), whole brain E14.5 (RPKM 4.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See B3gnt5 in Genome Data Viewer
Location:
16 A3; 16 12.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19578943..19591508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19760192..19772760)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated membrane protein 3 Neighboring gene STARR-seq mESC enhancer starr_40303 Neighboring gene STARR-seq mESC enhancer starr_40304 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40305 Neighboring gene STARR-seq mESC enhancer starr_40307 Neighboring gene RIKEN cDNA A930003A15 gene Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. Kuan CT, et al. BMC Dev Biol, 2010 Nov 18. PMID 21087515, Free PMC Article
  2. Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation. Togayachi A, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547865, Free PMC Article
  3. The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. Biellmann F, et al. BMC Dev Biol, 2008 Nov 12. PMID 19014510, Free PMC Article
  4. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. Togayachi A, et al. J Biol Chem, 2001 Jun 22. PMID 11283017
  5. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. Henion TR, et al. J Biol Chem, 2001 Aug 10. PMID 11384981

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that Lc3 synthase and lacto-neolacto series gangliosides are essential to multiple physiological functions, especially the control of reproductive output, and spleen B-cell abnormality.
    Title: Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
  2. B3gnt5 is essential to pre-implantation development of the murine embryo.
    Title: The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Names
BGnT-5
UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5
beta-1,3-Gn-T5
beta-1,3-N-acetylglucosaminyltransferase 5
beta3Gn-T5
lactotriaosylceramide synthase
lc(3)Cer synthase
lc3 synthase
NP_001152879.1
NP_001152880.1
NP_473393.2
XP_006521769.1
XP_030104776.1
XP_036015625.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159407.1 → NP_001152879.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

    See identical proteins and their annotated locations for NP_001152879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK037166, AK048010, AK083839, BB667148, BC063076, CN533455
    Consensus CDS
    CCDS28040.1
    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Related
    ENSMUSP00000126157.2, ENSMUST00000164397.8
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase

  2. NM_001159408.1 → NP_001152880.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

    See identical proteins and their annotated locations for NP_001152880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK037166, AK048010, BB667148, BC063076
    Consensus CDS
    CCDS28040.1
    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Related
    ENSMUSP00000112624.2, ENSMUST00000121344.8
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase

  3. NM_054052.3 → NP_473393.2  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

    See identical proteins and their annotated locations for NP_473393.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK083839, BB667148, BC063076
    Consensus CDS
    CCDS28040.1
    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Related
    ENSMUSP00000078712.4, ENSMUST00000079780.10
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19578943..19591508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248916.2 → XP_030104776.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase

  2. XM_036159732.1 → XP_036015625.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase

  3. XM_006521706.4 → XP_006521769.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006521769.1

    UniProtKB/Swiss-Prot
    Q810C6, Q8BGY6, Q923K7
    Related
    ENSMUSP00000113145.2, ENSMUST00000119468.2
    Conserved Domains (1) summary
    cl21608
    Location:101 → 297
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGY6.1 GenPept UniProtKB/Swiss-Prot:Q8BGY6

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