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NEU3 neuraminidase 3 [ Homo sapiens (human) ]

Gene ID: 10825, updated on 3-Apr-2024

Summary

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Official Symbol
NEU3provided by HGNC
Official Full Name
neuraminidase 3provided by HGNC
Primary source
HGNC:HGNC:7760
See related
Ensembl:ENSG00000162139 MIM:604617; AllianceGenome:HGNC:7760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAL3
Summary
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74980515..75020676)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74910079..74957510)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74699689..74721952)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene uncharacterized LOC107984352 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74644275-74644750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74659504-74660358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74660359-74661213 Neighboring gene signal peptidase complex subunit 2 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5261 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 pseudogene 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The extracellular sialidase NEU3 primes neutrophils. Kirolos SA, et al. J Leukoc Biol, 2022 Dec. PMID 35899930, Free PMC Article
  2. Sialidase NEU3 and its pathological significance. Miyagi T, et al. Glycoconj J, 2022 Oct. PMID 35675020
  3. Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines. Bovio F, et al. Int J Mol Sci, 2020 Nov 20. PMID 33233823, Free PMC Article
  4. Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation. Ghiroldi A, et al. Biochem J, 2020 Sep 18. PMID 32869836
  5. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis. Chen W, et al. Immunohorizons, 2020 Jun 23. PMID 32576593, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The extracellular sialidase NEU3 primes neutrophils.
    Title: The extracellular sialidase NEU3 primes neutrophils.
  2. Sialidase NEU3 and its pathological significance.
    Title: Sialidase NEU3 and its pathological significance.
  3. Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
    Title: Reduced Sialylation and Bioactivity of the Antifibrotic Protein Serum Amyloid P in the Sera of Patients with Idiopathic Pulmonary Fibrosis.
  4. TGF-beta1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
    Title: TGF-β1 increases sialidase 3 expression in human lung epithelial cells by decreasing its degradation and upregulating its translation.
  5. Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
    Title: Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
  6. Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
    Title: Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.
  7. overexpression of NEU3 in glioblastoma U87MG cells activates the PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation
    Title: Overexpression of sialidase NEU3 increases the cellular radioresistance potential of U87MG glioblastoma cells.
  8. this finding strongly supports the idea that Neu3 may contain a cytosolic-exposed domain.
    Title: Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein.
  9. This first demonstration of sialidase involvement in invasive potential of gliolastoma cells may point to NEU3 as an attractive treatment target of human gliomas
    Title: Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins.
  10. effect of overexpression on EGFR downstream pathway activation and TKI targeted therapies sensitivity in non-small cell lung cancer cell lines
    Title: Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed
env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-sialidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exo-alpha-(2->3)-sialidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exo-alpha-(2->3)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
  
enables exo-alpha-(2->8)-sialidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exo-alpha-(2->8)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exo-alpha-sialidase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid catabolic process TAS
Traceable Author Statement
more info
  
involved_in negative regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sialidase-3
Names
N-acetyl-alpha-neuraminidase 3
ganglioside sialidase
ganglioside sialidasedis
membrane sialidase
sialidase 3 (membrane sialidase)
NP_001354789.1
NP_001354790.1
NP_001354791.1
NP_001354792.1
NP_001354793.1
NP_001354794.1
NP_001354795.1
NP_001354796.1
NP_006647.3
XP_047282254.1
XP_047282255.1
XP_047282256.1
XP_047282257.1
XP_047282258.1
XP_047282259.1
XP_047282260.1
XP_054223493.1
XP_054223494.1
XP_054223495.1
XP_054223496.1
XP_054223497.1
XP_054223498.1
XP_054223499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367860.1 → NP_001354789.1  sialidase-3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AP001992, BC136397
    Consensus CDS
    CCDS44682.1
    UniProtKB/Swiss-Prot
    A8K327, Q9NQE1, Q9UQ49
    Related
    ENSP00000432097.1, ENST00000531509.5

  2. NM_001367861.1 → NP_001354790.1  sialidase-3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AP001992
    Consensus CDS
    CCDS91538.1
    UniProtKB/TrEMBL
    E9PNK1
    Conserved Domains (1) summary
    cd15482
    Location:44 → 93
    Sialidase_non-viral; Non-viral sialidases

  3. NM_001367862.1 → NP_001354791.1  sialidase-3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AP001992, DB099096
    Consensus CDS
    CCDS91538.1
    UniProtKB/TrEMBL
    E9PNK1
    Related
    ENSP00000434754.1, ENST00000534628.1
    Conserved Domains (1) summary
    cd15482
    Location:44 → 93
    Sialidase_non-viral; Non-viral sialidases

  4. NM_001367863.1 → NP_001354792.1  sialidase-3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AP001992
    Consensus CDS
    CCDS91539.1
    UniProtKB/TrEMBL
    E9PMZ3
    Related
    ENSP00000434474.1, ENST00000529024.1

  5. NM_001367864.1 → NP_001354793.1  sialidase-3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 5, encodes isoform c.
    Source sequence(s)
    AK303540, AP001992
    Consensus CDS
    CCDS91539.1
    UniProtKB/TrEMBL
    E9PMZ3
    Related
    ENSP00000434907.1, ENST00000532963.1

  6. NM_001367865.1 → NP_001354794.1  sialidase-3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AP001992

  7. NM_001367866.1 → NP_001354795.1  sialidase-3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AP001992, BP352846
    Consensus CDS
    CCDS91537.1
    UniProtKB/TrEMBL
    E9PR25
    Related
    ENSP00000436118.1, ENST00000531619.1
    Conserved Domains (1) summary
    cd15482
    Location:44 → 126
    Sialidase_non-viral; Non-viral sialidases

  8. NM_001367867.2 → NP_001354796.1  sialidase-3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AP001992, BX108543
    Consensus CDS
    CCDS91536.1
    UniProtKB/TrEMBL
    E9PI40
    Related
    ENSP00000436540.1, ENST00000526068.1

  9. NM_006656.6 → NP_006647.3  sialidase-3 isoform a

    See identical proteins and their annotated locations for NP_006647.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP001992, CN429425, DB240271
    Consensus CDS
    CCDS44682.1
    UniProtKB/Swiss-Prot
    A8K327, Q9NQE1, Q9UQ49
    Related
    ENSP00000294064.4, ENST00000294064.9
    Conserved Domains (2) summary
    cd15482
    Location:44 → 436
    Sialidase_non-viral; Non-viral sialidases
    pfam13088
    Location:70 → 417
    BNR_2; BNR repeat-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    74980515..75020676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426298.1 → XP_047282254.1  sialidase-3 isoform X1

  2. XM_047426304.1 → XP_047282260.1  sialidase-3 isoform X5

  3. XM_047426303.1 → XP_047282259.1  sialidase-3 isoform X4

  4. XM_047426302.1 → XP_047282258.1  sialidase-3 isoform X4

  5. XM_047426301.1 → XP_047282257.1  sialidase-3 isoform X3

    UniProtKB/TrEMBL
    B4E0V4

  6. XM_047426300.1 → XP_047282256.1  sialidase-3 isoform X3

    UniProtKB/TrEMBL
    B4E0V4

  7. XM_047426299.1 → XP_047282255.1  sialidase-3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    74910079..74957510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367518.1 → XP_054223493.1  sialidase-3 isoform X1

  2. XM_054367524.1 → XP_054223499.1  sialidase-3 isoform X5

  3. XM_054367523.1 → XP_054223498.1  sialidase-3 isoform X4

  4. XM_054367522.1 → XP_054223497.1  sialidase-3 isoform X4

  5. XM_054367521.1 → XP_054223496.1  sialidase-3 isoform X3

    UniProtKB/TrEMBL
    B4E0V4

  6. XM_054367520.1 → XP_054223495.1  sialidase-3 isoform X3

    UniProtKB/TrEMBL
    B4E0V4

  7. XM_054367519.1 → XP_054223494.1  sialidase-3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQ49.1 GenPept UniProtKB/Swiss-Prot:Q9UQ49

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