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LOC108281173 ZNF619P1-HMGN1P19 intergenic nontranscribed chromatin-defined enhancer [ Homo sapiens (human) ]

Gene ID: 108281173, updated on 10-Oct-2023

Summary

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Gene symbol
LOC108281173
Gene description
ZNF619P1-HMGN1P19 intergenic nontranscribed chromatin-defined enhancer
Gene type
biological region
Feature type(s)
regulatory: enhancer, epigenetically_modified_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic element is located in the intergenic region between the ZNF619P1 (zinc finger protein 619 pseudogene 1) and HMGN1P19 (high mobility group nucleosome binding domain 1 pseudogene 19) loci. It was defined as a nontranscribed region with regulatory potential based on the co-occurrence of H3K27ac and H3K4me1 ChIP-seq data centered on P300 binding sites in HeLa cells, with an absence of capped transcripts by cap analysis of gene expression (CAGE). It was validated as a functional enhancer by reporter assays in HeLa cells. [provided by RefSeq, Jul 2016]
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Genomic context

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Location:
7p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (46515578..46516237)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (46676949..46677608)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (46555176..46555835)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25973 Neighboring gene Sharpr-MPRA regulatory region 10400 Neighboring gene zinc finger protein 619 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:46245952-46247151 Neighboring gene Sharpr-MPRA regulatory region 2385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25974 Neighboring gene Sharpr-MPRA regulatory region 15376 Neighboring gene uncharacterized LOC105375266 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:46574043-46574599 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:46574600-46575155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:46576337-46576836 Neighboring gene NANOG hESC enhancer GRCh37_chr7:46666250-46666778 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:46690590-46691789 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 19 Neighboring gene uncharacterized LOC730338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An atlas of active enhancers across human cell types and tissues. Andersson R, et al. Nature, 2014 Mar 27. PMID 24670763, Free PMC Article
  2. An integrated encyclopedia of DNA elements in the human genome. ENCODE Project Consortium. Nature, 2012 Sep 6. PMID 22955616, Free PMC Article
  3. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ZNF619P1-HMGN1P19 interval no CAGE FANTOM5 enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051133.1 

    Range
    101..760
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    46515578..46516237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    46676949..46677608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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