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Eif5 eukaryotic translation initiation factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 108348073, updated on 2-Nov-2024

Summary

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Symbol
Eif5provided by RGD
Full Name
eukaryotic translation initiation factor 5provided by RGD
Primary source
RGD:619861
See related
EnsemblRapid:ENSRNOG00000010218 AllianceGenome:RGD:619861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
eIF-5
Summary
Enables eukaryotic initiation factor eIF2 binding activity and translation initiation factor activity. Involved in activation of GTPase activity and formation of translation preinitiation complex. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Eif5 in Genome Data Viewer
Location:
6q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136410333..136418827)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130589162..130597656)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136002962..136011409)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene TNF alpha induced protein 2 Neighboring gene DIRAS family GTPase 3 Neighboring gene uncharacterized LOC120103627 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene creatine kinase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic initiation factor eIF2 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of translation preinitiation complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5
Names
eukaryotic initiation factor 5
eukaryotic initiation factor 5 (eIF-5)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329879.2 → NP_001316808.1  eukaryotic translation initiation factor 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q07205
    UniProtKB/TrEMBL
    A0A8I6A040, A6KBR3
    Related
    ENSRNOP00000013695.6, ENSRNOT00000013695.9
    Conserved Domains (2) summary
    cd11561
    Location:231 → 383
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    136410333..136418827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111602.2 → XP_038967530.1  eukaryotic translation initiation factor 5 isoform X1

    UniProtKB/Swiss-Prot
    Q07205
    UniProtKB/TrEMBL
    A0A8I6A040, A6KBR3
    Conserved Domains (2) summary
    cd11561
    Location:231 → 383
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  2. XM_006240609.5 → XP_006240671.1  eukaryotic translation initiation factor 5 isoform X1

    See identical proteins and their annotated locations for XP_006240671.1

    UniProtKB/Swiss-Prot
    Q07205
    UniProtKB/TrEMBL
    A0A8I6A040, A6KBR3
    Conserved Domains (2) summary
    cd11561
    Location:231 → 383
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020075.1: Suppressed sequence

    Description
    NM_020075.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07205.1 GenPept UniProtKB/Swiss-Prot:Q07205

Gene LinkOut

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